Tousson Ehab
Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt
Toxicol Ind Health. 2016 Feb;32(2):299-305. doi: 10.1177/0748233713500821. Epub 2013 Oct 4.
Boldenone (BOL) is a derivative of the testosterone that has dual effects on humans, both directly and indirectly; directly as injection to build muscles and indirectly as through consuming meat of animals that where treated with BOL. However, the action of these steroids on different body organs structures is still unclear; therefore, the aim of the present study was to investigate the effect of the intramuscular injection of BOL undecylenate on the different organ structures. A total of 10 adult New Zealand rabbits were divided into two main groups, the first group was the control group, which includes animals that were injected intramuscularly with olive oil and the second group included animals that received two intramuscular injections of 5 mg/kg body weight BOL dissected after 6 weeks. Our results showed that intramuscular injection of rabbits with BOL showed hypertrophy in both skeletal and cardiac muscles, disturbances of the hepatocytes radially arranged cords with multifocal hepatocellular vacuolations in the liver, glomerulus mass reduction with multifocal glomerular injury in the kidney, disturbances of the cycle of spermatogenesis in the testes. In conclusion, using BOL, while preparing for a young bodybuilding contest, may cause an alteration in the histological structure of most of the body organs; these findings suggested that especially young people who misuse anablic androgenic steroids should be careful if they want to use such steroids to enhance their strength and endurance.
宝丹酮（BOL）是睾酮的衍生物，对人体有直接和间接的双重作用；直接作用是通过注射来增强肌肉，间接作用是通过食用用BOL处理过的动物肉类。然而，这些类固醇对不同身体器官结构的作用仍不清楚；因此，本研究的目的是调查肌肉注射十一酸宝丹酮对不同器官结构的影响。总共10只成年新西兰兔被分为两个主要组，第一组是对照组，包括肌肉注射橄榄油的动物，第二组包括在6周后接受两次5mg/kg体重BOL肌肉注射并解剖的动物。我们的结果表明，给兔子肌肉注射BOL后，骨骼肌和心肌均出现肥大，肝脏中肝细胞呈放射状排列的索状结构紊乱，伴有多灶性肝细胞空泡化，肾脏中肾小球质量减少，伴有多灶性肾小球损伤，睾丸中精子发生周期紊乱。总之，在为青少年健美比赛做准备时使用BOL可能会导致大多数身体器官的组织结构发生改变；这些发现表明，特别是滥用合成代谢雄激素类固醇的年轻人，如果想使用此类类固醇来增强力量和耐力，应该谨慎。
