Department of Pharmacology & Toxicology, College of Pharmacy, Qassim University, Qassim, Saudi Arabia.
Hormones Department, Medical Research Division, National Research Centre, Giza, Egypt.
Oxid Med Cell Longev. 2020 Jul 11;2020:1436858. doi: 10.1155/2020/1436858. eCollection 2020.
The main avoidable risk factor for cardiovascular conditions is high blood pressure (hypertension). At global level, hypertension is believed to be responsible for a 54% stroke-related mortality rate and a 47% mortality rate associated with coronary heart disease. It is postulated that sinapic acid (SA) could help in hypertension management because it displays robust antioxidant, antihyperglycemic, and peroxynitrite scavenging effects. To explore this hypothesis, this work examined the effect of SA on oxidative stress and cardiovascular disease in rats with hypertension by comparison against captopril. For this purpose, 50 male rats were used and equally allocated to five groups, namely, normal control, positive control (L-NAME), L-NAME with concomitant captopril administration, L-NAME with concomitant SA administration, and L-NAME with concomitant administration of both SA and captopril. Results showed that, by contrast to control, L-NAME exhibited marked elevation in serum CK-MB, total cholesterol, triglycerides, VLDL-C, LDL-C, Ang II, AT2R, ET-1, and angiopoietin-2; on the other hand, L-NAME exhibited marked reduction in serum HDL-C, superoxide dismutase (SOD) activity, nitric oxide synthase 3 (NOS3), and glutathione (GSH). Furthermore, joint administration of SA and captopril ameliorated hypertension, enhanced cardiovascular function, hindered hyperlipidemia, and decreased oxidative stress and myocardial hypertrophy displayed by rats with hypertension. Based on such findings, better chemopreventive or therapeutic approaches can be devised to manage hypertension and cardiovascular conditions.
心血管疾病的主要可避免风险因素是高血压（hypertension）。在全球范围内，高血压被认为是导致中风相关死亡率 54%和冠心病死亡率 47%的原因。有人假设芥子酸（sinapic acid，SA）可以帮助控制高血压，因为它具有强大的抗氧化、抗高血糖和过氧亚硝酸盐清除作用。为了验证这一假说，本研究通过与卡托普利（captopril）比较，观察了 SA 对高血压大鼠氧化应激和心血管疾病的影响。为此，使用了 50 只雄性大鼠，将它们平均分为五组，即正常对照组、阳性对照组（L-NAME）、L-NAME 与卡托普利同时给药组、L-NAME 与 SA 同时给药组和 L-NAME 与 SA 和卡托普利同时给药组。结果表明，与对照组相比，L-NAME 组大鼠血清肌酸激酶同工酶（CK-MB）、总胆固醇、甘油三酯、VLDL-C、LDL-C、血管紧张素 II（Ang II）、血管紧张素 II 受体 1（AT2R）、内皮素-1（ET-1）和血管生成素-2（angiopoietin-2）显著升高，而血清高密度脂蛋白胆固醇（HDL-C）、超氧化物歧化酶（SOD）活性、一氧化氮合酶 3（NOS3）和谷胱甘肽（GSH）则显著降低。此外，SA 和卡托普利联合给药可改善高血压大鼠的高血压、增强心血管功能、抑制高血脂症、减轻氧化应激和心肌肥厚。基于这些发现，可以设计更好的化学预防或治疗方法来管理高血压和心血管疾病。
