Hussain Eman M, Alkadhimy Sura M, Neamah Asmaa M, Tousson Ehab
Department of Biology, Collage of Science, Al-Qadisiyah University, Iraq.
Department of Hotel Studies, College of Tourism Sciences, University of Karbala, Iraq.
Toxicol Res (Camb). 2024 Mar 23;13(2):tfae042. doi: 10.1093/toxres/tfae042. eCollection 2024 Apr.
Millions of individuals have used illicit anabolic-androgenic steroids (AAS), but the long-term cardiovascular associations of these drugs remain incompletely understood. Boldjan is AAS medication which is used in veterinary medicine and by young adults aiming to have a better appearance improving their self-esteem. Therefore; the objective of the current investigation was to examine any potential preventative effects of amygdalin extract against anabolic steroid Boldjan induced cardic toxicity, injury and oxidative stress in male rat. Forty adult male Wistar rats were classified into five groups (Gp1, Control Gp; Gp2, Amygdalin Gp in which rats treated with amygdalin (100 mg/kg body weight/day) daily for 2 weeks; Gp3, Gp in which rats treated with (10 mg/Kg BW/week) for 4 weeks; Gp4, + Amygdalin). induced a significant rises in serum lactate dehydrogenase (LDH), creatine kinase (CK) and creatine kinase MB (CK MB), aspartate aminotransferase (AST), total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), and very-low-density lipoprotein-cholesterol (VLDL-C), cardiac injury, and malondialdehyde (MDA) levels and a significant depletion in serum high-density lipoprotein-cholesterol (HDL-C), cardiac reduced glutathione (GSH), Superoxide dismutase (SOD) and catalase (Cat) activities as compared to control Gp. In contrast, Amygdalin significantly reversed the induced cardiac toxicity in post treated rats Gp ( + Amygdalin). Amygdalin could be an efficient preventive supplement for mitigating induced cardiac toxicity, possibly via controlling oxidative stress events.
数以百万计的人使用过非法合成代谢雄激素类固醇（AAS），但这些药物与心血管系统的长期关联仍未完全明确。Boldjan是一种AAS药物，用于兽医学，也被一些年轻人使用，目的是改善外貌并提升自尊。因此，本研究的目的是检测苦杏仁苷提取物对合成代谢类固醇Boldjan诱导的雄性大鼠心脏毒性、损伤和氧化应激的潜在预防作用。40只成年雄性Wistar大鼠被分为五组（第1组，对照组；第2组，苦杏仁苷组，大鼠每天接受苦杏仁苷（100毫克/千克体重/天）治疗，持续2周；第3组，Boldjan组，大鼠每周接受Boldjan（10毫克/千克体重）治疗，持续4周；第4组，Boldjan + 苦杏仁苷组）。与对照组相比，Boldjan使血清乳酸脱氢酶（LDH）、肌酸激酶（CK）、肌酸激酶同工酶MB（CK MB）、天冬氨酸转氨酶（AST）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和极低密度脂蛋白胆固醇（VLDL-C）显著升高，导致心脏损伤、丙二醛（MDA）水平升高，血清高密度脂蛋白胆固醇（HDL-C）、心脏还原型谷胱甘肽（GSH）、超氧化物歧化酶（SOD）和过氧化氢酶（Cat）活性显著降低。相反，苦杏仁苷显著逆转了Boldjan对后处理大鼠（Boldjan + 苦杏仁苷组）诱导的心脏毒性。苦杏仁苷可能是一种有效的预防性补充剂，可减轻Boldjan诱导的心脏毒性，可能是通过控制氧化应激反应来实现的。
