Kreuzer Kenneth N
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710.
Cold Spring Harb Perspect Biol. 2013 Nov 1;5(11):a012674. doi: 10.1101/cshperspect.a012674.
Recent advances in the area of bacterial DNA damage responses are reviewed here. The SOS pathway is still the major paradigm of bacterial DNA damage response, and recent studies have clarified the mechanisms of SOS induction and key physiological roles of SOS including a very major role in genetic exchange and variation. When considering diverse bacteria, it is clear that SOS is not a uniform pathway with one purpose, but rather a platform that has evolved for differing functions in different bacteria. Relating in part to the SOS response, the field has uncovered multiple apparent cell-cycle checkpoints that assist cell survival after DNA damage and remarkable pathways that induce programmed cell death in bacteria. Bacterial DNA damage responses are also much broader than SOS, and several important examples of LexA-independent regulation will be reviewed. Finally, some recent advances that relate to the replication and repair of damaged DNA will be summarized.
本文综述了细菌DNA损伤反应领域的最新进展。SOS途径仍然是细菌DNA损伤反应的主要范例，最近的研究阐明了SOS诱导机制以及SOS的关键生理作用，包括在基因交换和变异中非常重要的作用。当考虑不同的细菌时，很明显SOS不是一个具有单一目的的统一途径，而是一个在不同细菌中为不同功能而进化的平台。部分与SOS反应相关，该领域发现了多个明显的细胞周期检查点，这些检查点有助于DNA损伤后细胞存活，以及诱导细菌程序性细胞死亡的显著途径。细菌DNA损伤反应也比SOS广泛得多，将综述几个不依赖LexA调控的重要例子。最后，将总结一些与受损DNA复制和修复相关的最新进展。
