Intelligent Automation, Inc., Rockville, MD, USA.
Int J Nanomedicine. 2013;8 Suppl 1(Suppl 1):15-29. doi: 10.2147/IJN.S40974. Epub 2013 Sep 18.
As more engineered nanomaterials (eNM) are developed for a wide range of applications, it is crucial to minimize any unintended environmental impacts resulting from the application of eNM. To realize this vision, industry and policymakers must base risk management decisions on sound scientific information about the environmental fate of eNM, their availability to receptor organisms (eg, uptake), and any resultant biological effects (eg, toxicity). To address this critical need, we developed a model-driven, data mining system called NEIMiner, to study nanomaterial environmental impact (NEI). NEIMiner consists of four components: NEI modeling framework, data integration, data management and access, and model building. The NEI modeling framework defines the scope of NEI modeling and the strategy of integrating NEI models to form a layered, comprehensive predictability. The data integration layer brings together heterogeneous data sources related to NEI via automatic web services and web scraping technologies. The data management and access layer reuses and extends a popular content management system (CMS), Drupal, and consists of modules that model the complex data structure for NEI-related bibliography and characterization data. The model building layer provides an advanced analysis capability for NEI data. Together, these components provide significant value to the process of aggregating and analyzing large-scale distributed NEI data. A prototype of the NEIMiner system is available at http://neiminer.i-a-i.com/.
随着越来越多的工程纳米材料（eNM）被开发用于广泛的应用，将 eNM 的应用所带来的任何意外的环境影响降到最低至关重要。为了实现这一愿景，工业界和政策制定者必须基于有关 eNM 的环境命运、其对受体生物的可获得性（例如摄取）以及任何由此产生的生物效应（例如毒性）的可靠科学信息来做出风险管理决策。为了满足这一关键需求，我们开发了一个称为 NEIMiner 的模型驱动的数据挖掘系统，用于研究纳米材料的环境影响（NEI）。NEIMiner 由四个组件组成：NEI 建模框架、数据集成、数据管理和访问以及模型构建。NEI 建模框架定义了 NEI 建模的范围以及整合 NEI 模型以形成分层、全面的可预测性的策略。数据集成层通过自动网络服务和网络抓取技术将与 NEI 相关的异构数据源整合在一起。数据管理和访问层重用并扩展了流行的内容管理系统（CMS）Drupal，并由用于为与 NEI 相关的文献和特征数据建模复杂数据结构的模块组成。模型构建层为 NEI 数据提供了高级分析能力。这些组件共同为聚合和分析大规模分布式 NEI 数据的过程提供了重要价值。NEIMiner 系统的原型可在 http://neiminer.i-a-i.com/ 上获得。
