Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center at Dallas, 5959 Harry Hines Boulevard, Suite 420, Dallas, TX 75390-8887, USA.
Clin Liver Dis. 2013 Nov;17(4):575-86, viii. doi: 10.1016/j.cld.2013.07.001. Epub 2013 Sep 4.
Although acute liver failure caused by drug-induced liver injury comprises a small fraction of overall drug-induced liver injury, these patients require high resource use and have relatively poor outcomes. Drug-induced liver injury caused by idiosyncrasy more often leads to death or transplantation than does acetaminophen acute liver failure, but the number of patients in each category receiving a graft is roughly the same. Efforts in the future to improve outcomes should focus on more effective treatments and better methods to identify those that might experience poor outcomes.
虽然药物性肝损伤导致的急性肝衰竭只占总体药物性肝损伤的一小部分，但这些患者需要大量的医疗资源，且预后相对较差。特异质药物性肝损伤比乙酰氨基酚性急性肝衰竭更常导致死亡或需要进行肝移植，但每个类别接受移植的患者数量大致相同。未来提高治疗效果的努力应集中在更有效的治疗方法和更好的方法来识别那些可能预后不良的患者。
