Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.
Vet Res. 2013 Oct 7;44(1):95. doi: 10.1186/1297-9716-44-95.
Porcine reproductive and respiratory syndrome virus (PRRSV)-induced reproductive problems are characterized by embryonic death, late-term abortions, early farrowing and increase in number of dead and mummified fetuses, and weak-born piglets. The virus recovery from fetal tissues illustrates transplacental infection, but despite many studies on the subject, the means by which PRRSV spreads from mother to fetus and the exact pathophysiological basis of the virus-induced reproductive failure remain unexplained. Recent findings from our group indicate that the endometrium and placenta are involved in the PRRSV passage from mother to fetus and that virus replication in the endometrial/placental tissues can be the actual reason for fetal death. The main purpose of this review is to clarify the role that PRRSV replication and PRRSV-induced changes in the endometrium/placenta play in the pathogenesis of PRRSV-induced reproductive failure in pregnant sows. In addition, strategies to control placental and transplacental PRRSV infection are discussed.
猪繁殖与呼吸综合征病毒（PRRSV）引起的繁殖问题的特征是胚胎死亡、晚期流产、早产和死胎木乃伊化数量增加，以及弱仔。从胎儿组织中回收病毒表明存在胎盘感染，但尽管对此进行了许多研究，但 PRRSV 从母体传播到胎儿的方式以及病毒引起的繁殖失败的确切病理生理基础仍未得到解释。我们小组的最新发现表明，子宫内膜和胎盘参与了 PRRSV 从母体到胎儿的传递，而子宫内膜/胎盘组织中的病毒复制可能是导致胎儿死亡的真正原因。本文的主要目的是阐明 PRRSV 复制和 PRRSV 引起的子宫内膜/胎盘变化在 PRRSV 引起妊娠母猪繁殖失败发病机制中的作用。此外，还讨论了控制胎盘和胎盘间 PRRSV 感染的策略。
