Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Avenue, Madison, Wisconsin 53705, USA.
J Nat Prod. 2012 Apr 27;75(4):735-40. doi: 10.1021/np300016r. Epub 2012 Apr 6.
A marine Nocardia sp. isolated from the ascidian Trididemnum orbiculatum was found to produce five new lipopeptides, peptidolipins B-F (1-5), which show distinct similarities to the previously reported L-Val(6) analog of peptidolipin NA. Synthetic modification of peptidolipin E (4) was used to determine the location of an olefin within the lipid chain. The advanced Marfey's method was used to determine the absolute configurations of the amino acids. Peptidolipins B (1) and E (4) demonstrated moderate antibacterial activity against methicillin-resistant Staphylococcus aureus and methicillin-sensitive Staphylococcus aureus.
从被囊动物 Trididemnum orbiculatum 中分离到的海洋诺卡氏菌产生了五个新的脂肽，即肽脂素 B-F（1-5），它们与先前报道的肽脂素 NA 的 L-Val（6）类似物表现出明显的相似性。对肽脂素 E（4）进行的合成修饰用于确定脂质链中烯烃的位置。先进的 Marfey 法用于确定氨基酸的绝对构型。肽脂素 B（1）和 E（4）对耐甲氧西林金黄色葡萄球菌和甲氧西林敏感金黄色葡萄球菌表现出中等的抗菌活性。
