Rasi V, Ikkala E, Torstila I
Thromb Res. 1982 Feb 1;25(3):203-12. doi: 10.1016/0049-3848(82)90239-0.
Serial measurements of plasma beta-thromboglobulin concentration were made in 25 patients with acute myocardial infarction. The beta-thromboglobulin level was elevated in 18 patients on the day of presentation and the mean beta-thromboglobulin of the patients (83 ng/ml) differed significantly from the normal mean (26 ng/ml; p less than 0.001). When grouped according to the clinical severity, the most severely affected patients had the highest values (mean 128 ng/ml; n = 11). Two patients with a mild or moderate clinical course had a normal beta-thromboglobulin level throughout the study. The patients showed a distinct pattern in the evolution of the plasma beta-thromboglobulin values. The initial elevation was followed by a decrease in beta-thromboglobulin levels (mean 37 ng/ml on day 3), when only the severely affected patients differed from the normals. The beta-thromboglobulin level started to increase thereafter, reaching in many cases the highest and in some cases the only abnormally high values at the end of the second week (mean 75 ng/ml) in the survivors. The levels were mostly normal again 4-6 months after the infarction.
对25例急性心肌梗死患者进行了血浆β-血小板球蛋白浓度的系列测定。18例患者在就诊当天β-血小板球蛋白水平升高，患者的平均β-血小板球蛋白水平（83 ng/ml）与正常平均值（26 ng/ml；p<0.001）有显著差异。根据临床严重程度分组时，受影响最严重的患者值最高（平均128 ng/ml；n = 11）。两名临床病程为轻度或中度的患者在整个研究过程中β-血小板球蛋白水平正常。患者血浆β-血小板球蛋白值的演变呈现出明显的模式。最初升高之后β-血小板球蛋白水平下降（第3天平均37 ng/ml），此时只有受影响严重的患者与正常患者不同。此后β-血小板球蛋白水平开始上升，在许多情况下在第二周结束时达到最高值，在某些情况下是唯一的异常高值（平均75 ng/ml），见于存活患者。梗死4 - 6个月后水平大多再次正常。
