Demol P, Singer M V, Hotz J, Eysselein V, Goebell H
Alcohol Alcohol. 1985;20(1):19-26.
The action of an intravenous infusion of ethanol (10% v/v; given in a dose of 300 mg kg-1 body weight for 30 min followed by 3 mg kg-1 min-1 for 2 hr) on the basal (= interdigestive) gastrointestinal motor activity and the basal gastric acid, pancreatic amylase and bile acid secretion was determined in 6 healthy human volunteers. Ethanol did not affect the duration of the interdigestive motor complex and the output of bile acids into the duodenum. Ethanol significantly (P less than 0.05) stimulated the gastric acid output by about 2.2-fold and inhibited the pancreatic amylase output by about 43% as compared to control experiments in which an intravenous infusion of 0.15 M NaCl was given. Ethanol did not alter the mean plasma levels of gastrin and pancreatic polypeptide as compared to prestimulatory values and to control experiments. In conclusion, these results show that intravenous ethanol given in a moderate dose stimulates gastric acid output and inhibits pancreatic amylase output in fasting non-alcoholic human beings. The mechanism(s) of these different actions of ethanol is unknown since release of gastrin or pancreatic polypeptide by ethanol does not account for the observed effects of intravenous ethanol.
在6名健康人类志愿者身上，测定了静脉输注乙醇（10% v/v；以300 mg/kg体重的剂量输注30分钟，随后以3 mg/kg体重·分钟的剂量输注2小时）对基础（即消化间期）胃肠运动活性以及基础胃酸、胰腺淀粉酶和胆汁酸分泌的作用。乙醇不影响消化间期运动复合波的持续时间以及胆汁酸进入十二指肠的输出量。与静脉输注0.15 M NaCl的对照实验相比，乙醇显著（P<0.05）刺激胃酸分泌约2.2倍，并抑制胰腺淀粉酶分泌约43%。与刺激前值及对照实验相比，乙醇未改变胃泌素和胰多肽的平均血浆水平。总之，这些结果表明，在禁食的非酒精性人类中，中等剂量静脉输注乙醇会刺激胃酸分泌并抑制胰腺淀粉酶分泌。乙醇这些不同作用的机制尚不清楚，因为乙醇释放胃泌素或胰多肽并不能解释静脉输注乙醇所观察到的效应。
