Department of Chemistry, Maharishi Markandeshwar University, Mullana, Ambala 133207, Haryana, India.
Eur J Med Chem. 2013 Nov;69:735-53. doi: 10.1016/j.ejmech.2013.08.053. Epub 2013 Sep 14.
A large number of structurally diverse natural compounds containing azole nucleus constitute an important class of biologically active heterocycles that are gaining more attention in the field of medicinal chemistry. Among azoles, pyrazoles are rarely found in nature probably due to difficulty in the formation of N-N bond by living organisms. However, they exhibit numerous biological activities, including anti-diabetic, antiviral, anticancer, anti-inflammatory, antibacterial and antifungal activities. The present review is an attempt to understand the chemistry along with medicinal importance of pyrazole containing natural products reported till date which would certainly help the scientific community to bring further developments in the isolation and synthetic methodologies for pyrazole based novel bioactive compounds.
大量含有唑核的结构多样的天然化合物构成了一类重要的具有生物活性的杂环，它们在药物化学领域越来越受到关注。在唑类化合物中，吡唑类化合物在自然界中很少见，可能是由于生物体很难形成 N-N 键。然而，它们表现出许多生物活性，包括抗糖尿病、抗病毒、抗癌、抗炎、抗菌和抗真菌活性。本综述试图了解迄今为止报道的含有吡唑的天然产物的化学性质及其医学重要性，这无疑将有助于科学界在基于吡唑的新型生物活性化合物的分离和合成方法方面取得进一步的发展。
