Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Prog Lipid Res. 2014 Oct;56:67-91. doi: 10.1016/j.plipres.2014.08.001. Epub 2014 Sep 1.
Currently, approximately 250 natural acetylenic epoxy structures are known. The present review describes research concerning biologically active epoxy acetylenic lipids and related compounds isolated from different sources. Intensive searches for new classes of pharmacologically potent agents produced by living organisms have resulted in the discovery of dozens of such compounds that possess high anticancer, cytotoxic, antibacterial, antiviral, and other activities. Acetylenic epoxides primarily belong to a class of molecules containing triple bond(s) and epoxy group(s) belonging to different lipid classes and/or other groups. This review emphasises natural and synthetic acetylenic epoxides and other related compounds as important sources of leads for drug discovery. The present review is the first article devoted to natural acetylenic epoxides.
目前，已知约有 250 种天然炔环氧结构。本综述描述了从不同来源分离出的具有生物活性的环氧炔脂类和相关化合物的研究。为了寻找具有强大药理活性的新型药物，人们对生物体内产生的化合物进行了深入研究，发现了数十种具有高抗癌、细胞毒性、抗菌、抗病毒等活性的化合物。炔环氧主要属于一类含有三键和环氧基团的分子，它们属于不同的脂质类和/或其他基团。本综述强调了天然和合成的炔环氧及其他相关化合物作为药物发现的重要先导化合物来源。这是第一篇专门讨论天然炔环氧的综述文章。
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