Wong O, Morgan R W, Kheifets L, Larson S R, Whorton M D
Br J Ind Med. 1985 Jul;42(7):435-48. doi: 10.1136/oem.42.7.435.
A historical prospective mortality study was conducted on a cohort of 34 156 male members of a heavy construction equipment operators union with potential exposure to diesel exhaust emissions. This cohort comprised all individuals who were members of the International Union of Operating Engineers, Locals 3 and 3A, for at least one year between 1 January 1964 and 31 December 1978. The mortality experience of the entire cohort and several subcohorts was compared with that of United States white men, adjusted for age and calendar time. The comparison statistic was the commonly used standardised mortality ratio (SMR). Historical environmental measurements did not exist, but partial work histories were available for some cohort members through the union dispatch computer tapes. An attempt was made to relate mortality experience to the union members' dispatch histories. Overall mortality for the entire cohort and several subgroups was significantly lower than expected. When cause specific mortality was examined, however, the study provided suggestive evidence for the existence of several potential health problems in this cohort. Mortality from liver cancer for the entire cohort was significantly high. Although mortality from lung cancer for the entire cohort was similar to expected, a positive trend by latency was observed for lung cancer. A significant excess of mortality from lung cancer was found among the retirees and the group for whom no dispatch histories were available. Other dispatch groups showed no evidence of lung cancer excess. In addition, the total cohort experienced significant mortality excess from emphysema and accidental deaths.
对一个有34156名重型建筑设备操作员工会男性会员的队列进行了一项历史性前瞻性死亡率研究,这些会员有可能接触柴油废气排放物。该队列包括在1964年1月1日至1978年12月31日期间至少有一年是国际操作工程师联盟3号和3A号地方分会会员的所有个人。将整个队列和几个亚组的死亡率情况与美国白人男性的死亡率情况进行了比较,并根据年龄和日历时间进行了调整。比较统计量是常用的标准化死亡率(SMR)。不存在历史环境测量数据,但通过工会调度计算机磁带可以获得一些队列成员的部分工作经历。试图将死亡率情况与工会成员的调度历史联系起来。整个队列和几个亚组的总体死亡率显著低于预期。然而,在检查特定病因死亡率时,该研究为该队列中存在几个潜在健康问题提供了提示性证据。整个队列的肝癌死亡率显著偏高。虽然整个队列的肺癌死亡率与预期相似,但观察到肺癌死亡率随潜伏期呈上升趋势。在退休人员和没有调度历史记录的组中发现肺癌死亡率显著过高。其他调度组没有显示出肺癌死亡率过高的证据。此外,整个队列的肺气肿和意外死亡死亡率显著过高。