aCedars-Sinai Medical Residency Program bGreater Los Angeles Veteran Affairs Healthcare System, WLAVA Medical Center cDepartment of Medicine dDepartment of Surgery, UCLA School of Medicine eCURE: Digestive Diseases Research Center Department of Medicine fBrentwood Biomedical Research Institute, Los Angeles, California, USA.
Curr Opin Gastroenterol. 2013 Nov;29(6):642-9. doi: 10.1097/MOG.0b013e328365d42e.
To review recent developments in the field of gastroduodenal mucosal defense.
Research in the field of gastroduodenal mucosal defense has focused on continued elucidation of molecular mechanisms that protect the mucosa and influence healing at the cellular level. Review of literature over the past year reveals focus on familiar processes such as superoxide dismutase, nitric oxide, heme oxygenase-1, neutrophil infiltration, cysteamine, mucin, hydrogen sulfide, ghrelin, adiponectin and the influence of Helicobacter pylori, but also brings into light new processes such as the balance between apoptosis and cellular proliferation, as well as the influence of other organ systems such as the bone marrow and central nervous system on the gastrointestinal tract.
These new published findings contribute to our overall understanding of gastroduodenal defense and suggest innovative avenues of future research and possible novel therapeutic targets.
综述胃十二指肠黏膜防御领域的最新进展。
胃十二指肠黏膜防御领域的研究集中于阐明保护黏膜和影响细胞水平愈合的分子机制。对过去一年文献的回顾表明，研究重点是熟悉的过程，如超氧化物歧化酶、一氧化氮、血红素加氧酶-1、中性粒细胞浸润、半胱胺、粘蛋白、硫化氢、胃饥饿素、脂联素以及幽门螺杆菌的影响，但也揭示了新的过程，如细胞凋亡和细胞增殖之间的平衡，以及骨髓和中枢神经系统等其他器官系统对胃肠道的影响。
这些新发表的发现有助于我们全面了解胃十二指肠防御，并为未来的研究和可能的新治疗靶点提供了创新途径。
