Kemmerly Thomas, Kaunitz Jonathan D
aCedars-Sinai Medical Residency Program bGreater Los Angeles Veteran Affairs Healthcare System, WLAVA Medical Center cDepartments of Medicine and Surgery, UCLA School of Medicine dDepartment of Medicine, CURE: Digestive Diseases Research Center eBrentwood Biomedical Research Institute, Los Angeles, California, USA.
Curr Opin Gastroenterol. 2014 Nov;30(6):583-8. doi: 10.1097/MOG.0000000000000124.
To review recent developments in the field of gastroduodenal mucosal defense.
Research in the field of gastroduodenal mucosal defense has focused on continued elucidation of molecular mechanisms that protect the mucosa and influence healing at the cellular level. Review of literature over the past year reveals that familiar proteins and mediators, such as nitric oxide, toll-like receptors, nucleotide-binding oligomerization domain-containing proteins (NOD2), β-defensins, macrophages, dendritic cells, mucins, autophagy, and the influence of aging and diet, are still subjects of study, but also brings into light new processes and mediators, such as dual oxidases, defense against radiation injuries, and novel proteins such as ZBP-89.
These new published findings contribute to our overall understanding of gastroduodenal defense and suggest innovative avenues of future research and possible novel therapeutic targets.
综述胃十二指肠黏膜防御领域的最新进展。
胃十二指肠黏膜防御领域的研究主要集中在持续阐明保护黏膜并在细胞水平影响愈合的分子机制。回顾过去一年的文献发现，一些为人熟知的蛋白质和介质，如一氧化氮、Toll样受体、含核苷酸结合寡聚化结构域蛋白（NOD2）、β-防御素、巨噬细胞、树突状细胞、黏蛋白、自噬以及衰老和饮食的影响，仍是研究对象，但同时也揭示了一些新的过程和介质，如双氧化酶、抗辐射损伤以及诸如ZBP-89等新蛋白质。
这些新发表的发现有助于我们全面理解胃十二指肠防御，并为未来研究提供了创新途径以及可能的新治疗靶点。
