van Tonder S, Kew M C, Hodkinson J, Metz J, Fernandes-Costa F
Cancer. 1985 Aug 15;56(4):789-92. doi: 10.1002/1097-0142(19850815)56:4<789::aid-cncr2820560415>3.0.co;2-i.
Sera from 242 South African blacks with hepatocellular carcinoma were assayed for unsaturated vitamin B12 binding capacity (UBBC) and vitamin B12 activity. Six patients were younger than 20 years of age, and 24% were younger than 30 years of age. Eighty-four percent of the patients had a slightly raised UBBC and 86% had a slightly elevated vitamin B12 value, but in no patient was an exceptionally high UBBC present. Serum UBBC and vitamin B12 were not higher in younger patients, and raised UBBC values were not related to serum alpha-fetoprotein values. Serum UBBC and vitamin B12 concentrations were not significantly different in patients with and without coexisting cirrhosis. In none of the patients with a UBBC above 3000 pg/ml was the fibrolamellar variant of hepatocellular carcinoma present. The authors conclude that South African blacks with hepatocellular carcinoma do not secrete an abnormal vitamin B12 binding protein.
对242例南非黑人肝细胞癌患者的血清进行了不饱和维生素B12结合能力（UBBC）和维生素B12活性检测。6例患者年龄小于20岁，24%的患者年龄小于30岁。84%的患者UBBC略有升高，86%的患者维生素B12值略有升高，但无一例患者的UBBC异常高。年轻患者的血清UBBC和维生素B12并不更高，UBBC升高值与血清甲胎蛋白值无关。有或无并存肝硬化的患者血清UBBC和维生素B12浓度无显著差异。在UBBC高于3000 pg/ml的患者中，均未出现肝细胞癌的纤维板层变体。作者得出结论，南非黑人肝细胞癌患者不分泌异常的维生素B12结合蛋白。
