Wheeler K, Pritchard J, Luck W, Rossiter M
Med Pediatr Oncol. 1986;14(4):227-9. doi: 10.1002/mpo.2950140408.
A 12 year old girl with a localised fibrolamellar hepatoma had a raised serum unsaturated vitamin B12 binding capacity (UBBC) and transcobalamin I (TCI) prior to complete resection and chemotherapy. Regular clinical and radiological follow-up detected no recurrence of her disease, but the UBBC and TCI slowly rose. Local recurrence and pulmonary metastases became detectable 2 1/2 years after diagnosis, 18 months after the UBBC and TCI level became elevated. Measurement of UBBC and TCI can help in the early detection of recurrence long before there is clinical or radiological evidence of recurrent fibrolamellar hepatoma.
一名患有局限性纤维板层状肝癌的12岁女孩，在完全切除和化疗前血清不饱和维生素B12结合能力（UBBC）和转钴胺素I（TCI）升高。定期的临床和影像学随访未发现疾病复发，但UBBC和TCI缓慢上升。诊断后2年半，即UBBC和TCI水平升高18个月后，发现局部复发和肺转移。在出现纤维板层状肝癌复发的临床或影像学证据之前很久，测量UBBC和TCI有助于早期发现复发。
