Kane S P, Murray-Lyon I M, Paradinas F J, Johnson P J, Williams R, Orr A H, Kohn J
Gut. 1978 Dec;19(12):1105-9. doi: 10.1136/gut.19.12.1105.
Grossly raised levels of tumour related vitamin B12 binding protein, reflected by rises in serum vitamin B12 and unsaturated vitamin B12 binding capacity (UBBC), were found in three of 44 patients with hepatocellular carcinoma. All three were HBsAg negative and had normal serum alpha fetoprotein levels. The patients did not have underlying cirrhosis and the tumours contained characteristic intracellular inclusions. In the first patient the UBBC level fell during a partial remission induced by adriamycin therapy and in the second patient UBBC levels rose with progression of her disease. In the third patient serum B12 binding protein levels fell after tumour resection. Assay and subsequent monitoring of serum vitamin B12 and UBCC may prove valuable in the assessment and follow-up of some patients with hepatocellular carcinoma whose alpha fetoprotein levels are normal.
在44例肝细胞癌患者中，有3例血清维生素B12和不饱和维生素B12结合能力（UBBC）升高，提示肿瘤相关维生素B12结合蛋白水平显著升高。这3例患者均为HBsAg阴性，血清甲胎蛋白水平正常。患者无潜在肝硬化，肿瘤含有特征性细胞内包涵体。第一例患者在阿霉素治疗诱导的部分缓解期，UBBC水平下降；第二例患者的UBBC水平随病情进展而升高。第三例患者肿瘤切除后，血清B12结合蛋白水平下降。对血清维生素B12和UBCC进行检测及后续监测，可能对评估和随访一些甲胎蛋白水平正常的肝细胞癌患者具有重要价值。
