Inst. of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang Univ, Hangzhou 310058, China.
J Food Sci. 2013 Nov;78(11):T1835-8. doi: 10.1111/1750-3841.12259. Epub 2013 Sep 16.
Aflatoxin M1 (AFM1 ) is a main cause of hepatocarcenogenoma in Chinese population. Measurement of aflatoxin exposure in human may help in providing clear evidence for the exposure of specific environmental pollutants in certain population. "One child policy" in China offered parents more careful to choose safe food during pregnancy, but no reports published on the efficacy of their endeavor. In present study, we aimed to assess the exposure of AFM1 in Chinese pregnant women. The urine samples were collected from 600 volunteers from Zhejiang province, China and the urinary concentration of AFM1 was measured using ELISA kit. AFM1 was detected in 84% of the pregnant women. The geometric mean and 95th percentile concentration of AFM1 in pregnant women were 50.3 ng/L and 633.5 ng/L, respectively. Our results point out that pregnant women especially are at the high risk of exposure to AFM1 . Our results also indicate that although "one child policy" offered parents to pay more attention for the selection of safe food, but detection of AFM1 in urine of pregnant women indicate that more foods containing AFM1 still need to be detected. Highest exposure of AFM1 in pregnant women indicates that awareness campaigns must be started especially in the rural areas of China regarding the possible hazardous effects of AFM1 exposure in pregnant women.
黄曲霉毒素 M1（AFM1）是导致中国人群肝癌的主要原因。对人体中黄曲霉毒素暴露的测量有助于为特定人群中特定环境污染物的暴露提供明确的证据。中国的“独生子女政策”使父母在怀孕期间更加小心地选择安全食品，但没有关于他们努力效果的报告发表。在本研究中，我们旨在评估中国孕妇的 AFM1 暴露情况。从中国浙江省的 600 名志愿者中采集了尿液样本，并使用 ELISA 试剂盒测量了尿液中 AFM1 的浓度。在 84%的孕妇中检测到了 AFM1。孕妇中 AFM1 的几何平均值和第 95 百分位数浓度分别为 50.3ng/L 和 633.5ng/L。我们的研究结果表明，孕妇特别是处于 AFM1 暴露的高风险中。我们的结果还表明，尽管“独生子女政策”使父母更加关注安全食品的选择，但孕妇尿液中 AFM1 的检测表明，仍需要检测更多含有 AFM1 的食品。孕妇中 AFM1 的最高暴露表明，必须在中国农村地区开展关于孕妇 AFM1 暴露可能带来的有害影响的宣传活动。
