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约旦患者中维生素D受体基因多态性与慢性重度牙周炎的关联

Association of vitamin D receptor gene polymorphisms with chronic and aggressive periodontitis in Jordanian patients.

作者信息

Karasneh Jumana A, Ababneh Khansa T, Taha Anas H, Al-Abbadi Muna S, Marzouka Nour al-Dain S, Jaradat Sameh M, Thornhill Martin H

机构信息

Department of Oral Medicine & Oral Surgery, Dental School, Jordan University of Science & Technology, Irbid, Jordan.

出版信息

Eur J Oral Sci. 2013 Dec;121(6):551-8. doi: 10.1111/eos.12085. Epub 2013 Sep 19.

Abstract

Vitamin D acts through binding with vitamin D receptor (VDR) and is responsible for regulating bone metabolism and mineralization; it also suppresses the immune system. The aim of this study was to investigate if VDR gene polymorphisms are associated with chronic periodontitis (CP) and aggressive periodontitis (AgP) in a Jordanian population. A total of 99 patients with CP, 63 patients with AgP, and 126 controls were genotyped using PCR-restriction fragment length polymorphism (RFLP) for BsmI, ApaI, and TaqI single nucleotide polymorphisms (SNPs). The association was determined after correcting for confounding factors using multivariate logistic regression analysis. Estimation of haplotype frequencies was carried out using the EH program, and haplotypes were constructed using the phase 2.1 program. After correcting for confounding factors, multivariate logistic regression analysis revealed that inheritance of the BsmI bb genotype or the ApaI aa genotype was associated with increased risk of developing CP (OR = 2.4 and OR = 3.4, respectively) but with reduced risk of developing AgP (OR = 0.4 and OR = 0.3, respectively). This was further supported by association of the ba haplotype with CP but not with AgP. This study supports an association of VDR gene polymorphisms with CP and AgP in a Jordanian population; however, the pattern of association was different between the two diseases.

摘要

维生素D通过与维生素D受体(VDR)结合发挥作用,负责调节骨代谢和矿化;它还会抑制免疫系统。本研究的目的是调查在约旦人群中VDR基因多态性是否与慢性牙周炎(CP)和侵袭性牙周炎(AgP)相关。使用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)对99例CP患者、63例AgP患者和126例对照进行BsmI、ApaI和TaqI单核苷酸多态性(SNP)基因分型。在使用多因素逻辑回归分析校正混杂因素后确定相关性。使用EH程序估计单倍型频率,并使用phase 2.1程序构建单倍型。校正混杂因素后,多因素逻辑回归分析显示,BsmI bb基因型或ApaI aa基因型的遗传与发生CP的风险增加相关(OR分别为2.4和3.4),但与发生AgP的风险降低相关(OR分别为0.4和0.3)。ba单倍型与CP相关但与AgP无关进一步支持了这一点。本研究支持在约旦人群中VDR基因多态性与CP和AgP相关;然而,两种疾病之间的关联模式不同。

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