[牙周炎患者维生素D受体基因多态性的相关性研究]

[Correlation study on polymorphisms of vitamin D receptor gene in patients with periodontitis].

作者信息

Zhang Li, Meng Huan-xin, Zhao Hong-shan, Li Qi-yan, Xu Li, Chen Zhi-bin, Shi Dong, Feng Xiang-hui

机构信息

Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China.

出版信息

Beijing Da Xue Xue Bao Yi Xue Ban. 2010 Feb 18;42(1):37-40.

PMID:20140040

Abstract

OBJECTIVE

To investigate the relationship between vitamin D receptor (VDR) gene polymorphisms and periodontitis.

METHODS

Ninety patients with aggressive periodontitis(AgP), 34 patients with chronic periodontitis and 91 healthy controls were recruited in this study. VDR gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with Taq I restriction endonuclease.

RESULTS

The detection frequency of Tt genotype was higher in the aggressive periodontitis patients than in the healthy controls (16.7% vs 7.7%, P>0.05). The difference between the female aggressive periodontitis patients and healthy controls (20.8% vs 4.2%, P<0.05) was statistically significant, but no difference was found between the male patients and controls (10.8% vs 11.6%, P>0.05). There was a strong association between aggressive periodontitis and Tt genotype in females (AgP patients vs healthy controls, OR=6.02). The detection frequency of Taq I ER-alpha genotypes was not statistically different between the chronic periodontitis patients and healthy controls.

CONCLUSION

In female Han Chinese population, the Tt VDR genotype may be associated with aggressive periodontitis.

摘要

目的

探讨维生素D受体（VDR）基因多态性与牙周炎之间的关系。

方法

本研究招募了90例侵袭性牙周炎（AgP）患者、34例慢性牙周炎患者和91例健康对照者。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术，用Taq I限制性内切酶对VDR基因进行分析。

结果

侵袭性牙周炎患者中Tt基因型的检测频率高于健康对照者（16.7%对7.7%，P>0.05）。女性侵袭性牙周炎患者与健康对照者之间的差异具有统计学意义（20.8%对4.2%，P<0.05），但男性患者与对照者之间未发现差异（10.8%对11.6%，P>0.05）。女性侵袭性牙周炎与Tt基因型之间存在强关联（AgP患者对健康对照者，OR=6.02）。慢性牙周炎患者与健康对照者之间Taq I ER-α基因型的检测频率无统计学差异。