Fernandez L A, Tarlatzis B C, Rzasa P J, Caride V J, Laufer N, Negro-Vilar A F, DeCherney A H, Naftolin F
Fertil Steril. 1985 Aug;44(2):219-23. doi: 10.1016/s0015-0282(16)48740-6.
Angiogenesis is a feature of ovarian follicle and corpus luteum development. Ovarian homogenates and follicular fluid (FF) contain factors that stimulate new vessel formation. Because the renin-angiotensin system has been shown to facilitate angiogenesis, renin activity was measured in FF and plasma from 20 normal, ovulatory women who were undergoing in vitro fertilization and were therefore stimulated with human menopausal gonadotropin/human chorionic gonadotropin. Serum estradiol (E2) and FF E2 and progesterone (P) were also determined and correlated with FF and plasma renin activity. FF renin activity was significantly higher than plasma renin activity (55.8 +/- 7.9 versus 3.8 +/- 0.7 ng of angiotensin I/ml/hour, P less than 0.001). Positive correlations were found between FF E2 and renin activity (r = 0.53, P less than 0.05). There was also a correlation between plasma renin activity and serum E2 (r = 0.69, P less than 0.05). No correlation was present between FF P and renin activity. The high renin-like activity present in FF after stimulation with gonadotropins could be involved in the mechanism of angiogenesis and may play an important role in events related to reproductive processes.
血管生成是卵巢卵泡和黄体发育的一个特征。卵巢匀浆和卵泡液（FF）含有刺激新血管形成的因子。由于肾素-血管紧张素系统已被证明有助于血管生成，因此对20名接受体外受精并因此接受人绝经期促性腺激素/人绒毛膜促性腺激素刺激的正常排卵女性的卵泡液和血浆中的肾素活性进行了测量。还测定了血清雌二醇（E2）、卵泡液E2和孕酮（P），并将其与卵泡液和血浆肾素活性相关联。卵泡液肾素活性显著高于血浆肾素活性（55.8±7.9对3.8±0.7 ng血管紧张素I/ml/小时，P<0.001）。卵泡液E2与肾素活性之间呈正相关（r = 0.53，P<0.05）。血浆肾素活性与血清E2之间也存在相关性（r = 0.69，P<0.05）。卵泡液P与肾素活性之间无相关性。促性腺激素刺激后卵泡液中存在的高肾素样活性可能参与血管生成机制，并可能在与生殖过程相关的事件中发挥重要作用。
