Dorf M E, Benacerraf B
Immunol Rev. 1985 Apr;83:23-40. doi: 10.1111/j.1600-065x.1985.tb00468.x.
This review attempts to sort out the differences between macrophage and T cell I-J determinants. We propose that suppressor T cells have receptors for self-I-J determinants which are expressed on macrophage-like accessory cells. The I-J determinants associated with accessory cells are responsible for the selection of the Ts receptors. Although the major histocompatibility complex is involved in the selection of Ts receptors, the receptors themselves need not be encoded by genes which reside within the MHC. In fact, the molecular genetic evidence presently available has established that suppressor T cell factors do not express gene products associated with the postulated I-J region of the H-2 complex. In spite of the failures of biochemists and molecular geneticists to identify I-J genes and gene products, there is extensive biological data demonstrating the existence of I-J. The activity of anti-I-J reagents has been verified by numerous laboratories. Sera containing anti-I-J activity have been prepared in many strain combinations. Immunization between a variety of strains differing at the purported I-J region produce active anti-I-J antibodies (Murphy et al. 1976, Tada et al. 1976, Pierres et al. 1977, Tada et al. 1978). Furthermore, in many suppressor cell systems the interactions of Ts cells and factors are restricted by I-J (Tada & Okumara 1980, Sorensen & Pierce 1982, Green et al. 1983, Dorf & Benacerraf 1984). Most investigators who have attempted to detect I-J have analyzed T cells. Since we propose that T cells express a complementary anti-I-J receptor, subsequent efforts at identifying I-J should include analysis of macrophage I-J determinants. In spite of extensive biological data, we still do not know if I-J is a protein, carbohydrate or lipid. In addition, the role of H-2 in determining I-J structure is unknown. Nevertheless, the overwhelming biological data demonstrate that I-J is an important structure for suppressor T cell interactions. Much remains to be accomplished, including the characterization of I-J products and locating the I-J genes.
本综述试图梳理巨噬细胞和T细胞I-J决定簇之间的差异。我们提出，抑制性T细胞具有针对自身I-J决定簇的受体，这些决定簇在巨噬细胞样辅助细胞上表达。与辅助细胞相关的I-J决定簇负责Ts受体的选择。虽然主要组织相容性复合体参与Ts受体的选择，但受体本身不一定由位于MHC内的基因编码。事实上，目前可得的分子遗传学证据已经证实，抑制性T细胞因子不表达与H-2复合体假定的I-J区域相关的基因产物。尽管生物化学家和分子遗传学家未能鉴定出I-J基因和基因产物，但有大量生物学数据证明I-J的存在。抗I-J试剂的活性已得到众多实验室的验证。在许多品系组合中都制备了含有抗I-J活性的血清。在假定的I-J区域存在差异的各种品系之间进行免疫可产生活性抗I-J抗体（墨菲等人，1976年；田代等人，1976年；皮埃尔等人，1977年；田代等人，1978年）。此外，在许多抑制性细胞系统中，Ts细胞与因子之间的相互作用受I-J限制（田代和奥村，1980年；索伦森和皮尔斯，1982年；格林等人，1983年；多夫和贝纳塞拉夫，1984年）。大多数试图检测I-J的研究人员都分析了T细胞。由于我们提出T细胞表达互补的抗I-J受体，因此后续鉴定I-J的工作应包括对巨噬细胞I-J决定簇的分析。尽管有大量生物学数据，但我们仍然不知道I-J是蛋白质、碳水化合物还是脂质。此外，H-2在决定I-J结构中的作用尚不清楚。然而，压倒性的生物学数据表明，I-J是抑制性T细胞相互作用的重要结构。仍有许多工作要完成，包括I-J产物的表征和I-J基因定位。
