Nakamura R M, Nakamura Y, Nagayama A, Tokunaga T
Immunol Res. 1986;5(2):106-16. doi: 10.1007/BF02917585.
I-A+/I-J+ cloned macrophages, SL-1, played the role of APC in the in vitro induction of Ts against DTH to BCG. By treating SL-1 cells with various antibodies, it was shown that I-J antigens on SL-1 cells are essential for Ts induction, but not for the effector cell induction for DTH. Ia-negative cloned macrophages, SL-4, did not show any APC activity either in suppressor or effector cell induction. The precursors of the Ts were also I-J-positive, and I-J restriction resided between T cells and macrophages in the Ts induction. Thus, it is suggested that the pre-Ts recognizes the antigenic determinants of BCG presented on the APC in association with the I-J antigen and differentiates into the Ts. This pathway seems analogous to that of helper or effector T induction, where the antigenic determinant is recognized by a T cell in association with the I-A antigen on APC.
I-A+/I-J+克隆巨噬细胞SL-1在体外诱导针对卡介苗迟发型超敏反应的抑制性T细胞（Ts）中起抗原呈递细胞（APC）的作用。通过用各种抗体处理SL-1细胞表明，SL-1细胞上的I-J抗原对于Ts诱导是必不可少的，但对于迟发型超敏反应效应细胞的诱导并非如此。Ia阴性克隆巨噬细胞SL-4在抑制性或效应细胞诱导中均未表现出任何APC活性。Ts的前体细胞也是I-J阳性的，并且在Ts诱导中T细胞和巨噬细胞之间存在I-J限制。因此，提示前Ts识别与I-J抗原相关联呈递在APC上的卡介苗抗原决定簇并分化为Ts。该途径似乎类似于辅助性或效应性T细胞诱导途径，其中抗原决定簇由T细胞与APC上的I-A抗原相关联识别。
