Yuan B D, Wu R T, Sato I, Okabe T, Suzuki H, Nishimura T, Tanaka N
J Antibiot (Tokyo). 1985 May;38(5):642-8. doi: 10.7164/antibiotics.38.642.
Cadeguomycin retarded growth of sc solid IMC carcinoma in CDF1 mice, and pulmonary metastasis of Lewis lung carcinoma in C57BL/6 mice. The antibiotic enhanced phagocytic activity of murine peritoneal macrophages and IL-1 production by P388D1 cells. Delayed type hypersensitivity was stimulated and interferon was induced by the drug. The results suggest that cadeguomycin inhibits tumor growth and metastasis in association with modification of the immune system. The cytotoxicity of arabinosylcytosine to K562 and YAC-1 cells was markedly enhanced by cadeguomycin in culture. The combined administration of arabinosylcytosine and cadeguomycin displayed potentiation in the inhibition of growth of ip-implanted P388 leukemia and metastasis of sc-implanted P388 leukemia to the regional lymph nodes. Cadeguomycin showed low toxicity for mice.
卡德古霉素抑制了CDF1小鼠中皮下实体IMC癌的生长以及C57BL/6小鼠中Lewis肺癌的肺转移。该抗生素增强了小鼠腹腔巨噬细胞的吞噬活性以及P388D1细胞的白细胞介素-1生成。该药物刺激了迟发型超敏反应并诱导了干扰素。结果表明，卡德古霉素与免疫系统的调节相关联，抑制肿瘤生长和转移。在培养中，卡德古霉素显著增强了阿糖胞苷对K562和YAC-1细胞的细胞毒性。阿糖胞苷与卡德古霉素联合给药在抑制腹腔注射植入的P388白血病生长以及皮下植入的P388白血病向局部淋巴结转移方面表现出增效作用。卡德古霉素对小鼠显示出低毒性。
