Katz H R, Stevens R L, Austen K F
J Allergy Clin Immunol. 1985 Aug;76(2 Pt 2):250-9. doi: 10.1016/0091-6749(85)90638-4.
The evidence for mast cell heterogeneity in vivo has grown in the last several years from the initial morphologic and histochemical observations to biochemical and functional criteria. In several species, there appear to be at least two distinct classes of tissue mast cells that differ in their content of intragranular amines, proteoglycans, and proteases and in their metabolism of arachidonic acid after cell activation. With the recent discovery of differentiation/growth factors for mast cells in vitro, it has been shown that a discrete subpopulation of cells resembling one of the two in vivo classes can be derived in culture. The diversity of mast cell mediators synthesized by these various populations and their potential functions in vivo imply that mast cells may be involved not only in allergic responses but also in other inflammatory processes, including tissue repair and growth.
在过去几年中，体内肥大细胞异质性的证据已从最初的形态学和组织化学观察发展到生化和功能标准。在几个物种中，似乎至少有两类不同的组织肥大细胞，它们在颗粒内胺、蛋白聚糖和蛋白酶的含量以及细胞活化后花生四烯酸的代谢方面存在差异。随着最近体外肥大细胞分化/生长因子的发现，已表明在培养中可以衍生出类似于体内两类之一的离散细胞亚群。这些不同群体合成的肥大细胞介质的多样性及其在体内的潜在功能意味着肥大细胞可能不仅参与过敏反应，还参与其他炎症过程，包括组织修复和生长。
