Department of Orthopaedics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Future Oncol. 2013 Oct;9(10):1515-31. doi: 10.2217/fon.13.124.
At present, the treatment strategies in patients with localized and diffuse forms of pigmented villonodular synovitis have more or less been standardized. However, these strategies are not optimal because high recurrence rates persist and studies with a sufficient level of evidence are lacking. This systematic review article describes all known treatment options for intra-articular pigmented villonodular synovitis and their clinical results. Based on this research, we provide guidelines to support physicians in making the optimal treatment decisions. Given the rarity of the disease, randomized studies are not to be expected, but an international registry through existing networks would offer the benefit of getting a better insight into the outcome of this disease. Therefore, we propose a basic set of data to be investigated and ideally to be reported on in such a registry.
目前，局限性和弥漫性色素绒毛结节性滑膜炎患者的治疗策略或多或少已经标准化。然而，这些策略并不理想，因为高复发率仍然存在，并且缺乏足够证据水平的研究。本文系统地回顾了所有已知的关节内色素绒毛结节性滑膜炎的治疗选择及其临床结果。在此基础上，我们为医生提供了指导方针，以帮助他们做出最佳的治疗决策。鉴于该疾病的罕见性，预计不会有随机研究，但通过现有网络建立一个国际登记处将有助于更好地了解该疾病的结果。因此，我们提出了一套基本的数据进行调查，并理想情况下在这样的登记处报告。
