de Bont A J, Romsos D R, Tsai A C, Waterman R A, Leveille G A
Proc Soc Exp Biol Med. 1975 Sep;149(4):849-54. doi: 10.3181/00379727-149-38912.
Rats were allowed to eat only 2 hr per day (meal-fed) or were fed ad libitum (nibbler) for 12 wk; another group of animals was meal-fed for 3 wk and then fed ad libitum (converted I) while the fourth group of rats (converted II) was meal-fed for 3 wk, allowed to nibble for the next 3 wk, meal-fed from the 6th to 9th wk and then returned to ad libitum feeding for the last 3 wk. Body fat gain and food efficiency was increased in converted I rats. The lipogenic capacity of adipose tissue from meal-fed rats was greater than observen meal-fed rats were reverted to ad libitum feeding whereas lipogenic activity increased rapidly when ad libitum fed rats were switched to meal-feeding.
大鼠每天仅被允许进食2小时（定时喂食）或随意进食12周（自由采食）；另一组动物先定时喂食3周，然后改为随意进食（转换I），而第四组大鼠（转换II）先定时喂食3周，接下来3周自由采食，第6至9周定时喂食，最后3周再恢复为随意进食。转换I组大鼠的体脂增加量和食物效率有所提高。定时喂食大鼠的脂肪组织生脂能力大于观察到的情况，当定时喂食大鼠恢复为随意进食时，而生脂活性在自由采食大鼠改为定时喂食时迅速增加。
