Departments of Neurology and Stereotactic Neurosurgery, Otto-von-Guericke University Magdeburg, Germany ; Department of Behavioural Neurology, Leibniz Institute for Neurobiology Magdeburg, Germany.
Front Hum Neurosci. 2013 Oct 7;7:635. doi: 10.3389/fnhum.2013.00635. eCollection 2013.
The Nucleus Accumbens (NAcc) is an important structure for the transfer of information between cortical and subcortical structures, especially the prefrontal cortex and the hippocampus. However, the mechanism that allows the NAcc to achieve this integration is not well understood. Phase-amplitude cross-frequency coupling (PAC) of oscillations in different frequency bands has been proposed as an effective mechanism to form functional networks to optimize transfer and integration of information. Here we assess PAC between theta and high gamma oscillations as a potential mechanism that facilitates motor adaptation. To address this issue we recorded intracranial field potentials directly from the bilateral human NAcc in three patients while they performed a motor learning task that varied in the level of cognitive control needed to perform the task. As in rodents, PAC was observable in the human NAcc, transiently occurring contralateral to a movement following the motor response. Importantly, PAC correlated with the level of cognitive control needed to monitor the action performed. This functional relation indicates that the NAcc is engaged in action monitoring and supports the evaluation of motor programs during adaptive behavior by means of PAC.
伏隔核（NAcc）是皮质和皮质下结构（特别是前额叶皮层和海马体）之间信息传递的重要结构。然而，允许 NAcc 实现这种整合的机制尚不清楚。不同频带的振荡的相位-幅度交叉频耦合（PAC）已被提议作为形成功能网络的有效机制，以优化信息的传递和整合。在这里，我们评估θ和高γ振荡之间的 PAC 作为促进运动适应的潜在机制。为了解决这个问题，我们在三名患者中直接记录了双侧人类 NAcc 的颅内电场电位，同时他们执行了一项运动学习任务，该任务需要不同程度的认知控制来执行任务。与啮齿动物一样，人类 NAcc 中也可以观察到 PAC，它在运动反应后短暂地出现在对侧。重要的是，PAC 与执行动作所需的认知控制水平相关。这种功能关系表明 NAcc 参与了动作监测，并通过 PAC 支持在自适应行为期间对运动程序进行评估。
