Stenner Max-Philipp, Litvak Vladimir, Rutledge Robb B, Zaehle Tino, Schmitt Friedhelm C, Voges Jürgen, Heinze Hans-Jochen, Dolan Raymond J
Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom; Department of Neurology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany;
Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom;
J Neurophysiol. 2015 Jul;114(1):29-39. doi: 10.1152/jn.00988.2014. Epub 2015 Apr 15.
The nucleus accumbens is thought to contribute to action selection by integrating behaviorally relevant information from multiple regions, including prefrontal cortex. Studies in rodents suggest that information flow to the nucleus accumbens may be regulated via task-dependent oscillatory coupling between regions. During instrumental behavior, local field potentials (LFP) in the rat nucleus accumbens and prefrontal cortex are coupled at delta frequencies (Gruber AJ, Hussain RJ, O'Donnell P. PLoS One 4: e5062, 2009), possibly mediating suppression of afferent input from other areas and thereby supporting cortical control (Calhoon GG, O'Donnell P. Neuron 78: 181-190, 2013). In this report, we demonstrate low-frequency cortico-accumbens coupling in humans, both at rest and during a decision-making task. We recorded LFP from the nucleus accumbens in six epilepsy patients who underwent implantation of deep brain stimulation electrodes. All patients showed significant coherence and phase-synchronization between LFP and surface EEG at delta and low theta frequencies. Although the direction of this coupling as indexed by Granger causality varied between subjects in the resting-state data, all patients showed a cortical drive of the nucleus accumbens during action selection in a decision-making task. In three patients this was accompanied by a significant coherence increase over baseline. Our results suggest that low-frequency cortico-accumbens coupling represents a highly conserved regulatory mechanism for action selection.
伏隔核被认为通过整合来自包括前额叶皮质在内的多个区域的行为相关信息来促进动作选择。对啮齿动物的研究表明，流向伏隔核的信息流可能通过区域间任务依赖的振荡耦合来调节。在工具性行为期间，大鼠伏隔核和前额叶皮质中的局部场电位（LFP）在δ频率下耦合（格鲁伯AJ、侯赛因RJ、奥唐奈P。《公共科学图书馆·综合》4：e5062，2009），这可能介导对来自其他区域的传入输入的抑制，从而支持皮质控制（卡尔洪GG、奥唐奈P。《神经元》78：181 - 190，2013）。在本报告中，我们证明了人类在静息状态和决策任务期间存在低频皮质 - 伏隔核耦合。我们记录了6名接受深部脑刺激电极植入的癫痫患者伏隔核的LFP。所有患者在δ和低θ频率下LFP与头皮脑电图之间均表现出显著的相干性和相位同步。尽管在静息状态数据中，由格兰杰因果关系索引的这种耦合方向在不同受试者之间有所不同，但在决策任务的动作选择过程中，所有患者均表现出伏隔核的皮质驱动。在3名患者中，这伴随着相对于基线的显著相干性增加。我们的结果表明，低频皮质 - 伏隔核耦合代表了一种高度保守的动作选择调节机制。
