用原钒酸钠刺激肥大细胞后组胺的分泌。
Histamine secretion from mast cells stimulated with sodium orthovanadate.
作者信息
al-Laith M, Pearce F L
机构信息
Department of Chemistry, University College London, UK.
出版信息
Agents Actions. 1988 Apr;23(3-4):168-9. doi: 10.1007/BF02142530.
PMID:2455979
Abstract
Sodium orthovanadate was found to be an effective histamine liberator from peritoneal mast cells of the rat and mouse. The release process was slow, non-cytotoxic and strongly dependent on pH and extracellular calcium. The effect was highly tissue and species specific and human basophil leucocytes and tissue mast cells of the rat and guinea pig were only weakly responsive or essentially unreactive.
摘要
已发现原钒酸钠是大鼠和小鼠腹膜肥大细胞中一种有效的组胺释放剂。释放过程缓慢，无细胞毒性，且强烈依赖于pH值和细胞外钙。这种作用具有高度的组织和物种特异性，人类嗜碱性白细胞以及大鼠和豚鼠的组织肥大细胞只有微弱反应或基本无反应。
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