Kreuser E D, Seifried E, Harsch U, Brass B, Schreml W, Heimpel H
Dtsch Med Wochenschr. 1985 Sep 6;110(36):1365-8. doi: 10.1055/s-2008-1069011.
Fibrin pleurodesis was performed on 30 patients with malignant pleural effusions. A pleural catheter was inserted to empty the pleural space and effect the pleurodesis. When the pleural space was dry, 20 000 U of aprotinin were instilled intrapleurally for local fibrinolysis inhibition. 10 ml fibrinogen concentrate and 10 ml thrombin (500 U/ml) and 3000 KI U/ml aprotinin were then applied. Complete success was achieved in 19 of 27 patients, partial success in two. The results could not be evaluated in three patients. The only side-effect of the treatment was a subfebrile temperature in three of the 30 patients. Fibrin pleurodesis thus proved itself as an effective form of treatment with few side-effects (10%).
对30例恶性胸腔积液患者实施了纤维蛋白粘连术。插入一根胸膜导管以排空胸腔并实现胸膜粘连。当胸腔干燥后，向胸腔内注入20000 U抑肽酶以抑制局部纤维蛋白溶解。然后应用10 ml纤维蛋白原浓缩物、10 ml凝血酶（500 U/ml）和3000 KIU/ml抑肽酶。27例患者中有19例完全成功，2例部分成功。3例患者的结果无法评估。治疗的唯一副作用是30例患者中有3例出现低热。因此，纤维蛋白粘连术证明是一种有效的治疗方式，副作用较少（10%）。
