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转化玻璃体蛋白质组学。

Translational vitreous proteomics.

机构信息

Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA; Omics Laboratory, University of Iowa, Iowa City, IA, USA.

出版信息

Proteomics Clin Appl. 2014 Apr;8(3-4):204-8. doi: 10.1002/prca.201300062. Epub 2013 Nov 4.

DOI:10.1002/prca.201300062
PMID:24115652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3964148/
Abstract

The vitreous is an extracellular matrix that is still poorly understood. Although many constituents and characteristics have been previously determined, there are many attributes still being discovered. Currently, using protein arrays, MS, and bioinformatics, the vitreous provides a wealth of knowledge regarding ocular diseases and potential targets for personalized therapeutics.

摘要

玻璃体是一种细胞外基质，目前人们对其了解甚少。尽管之前已经确定了许多成分和特征，但仍有许多属性有待发现。目前，通过蛋白质阵列、MS 和生物信息学，玻璃体为眼部疾病和潜在的个体化治疗靶点提供了丰富的知识。

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本文引用的文献

1
An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks.免疫球蛋白和富含亮氨酸重复序列蛋白的细胞外相互作用组揭示了受体-配体网络。
Cell. 2013 Jul 3;154(1):228-39. doi: 10.1016/j.cell.2013.06.006.
2
Surgical management of fibrotic encapsulation of the fluocinolone acetonide implant in CAPN5-associated proliferative vitreoretinopathy.醋酸氟轻松植入物在CAPN5相关增殖性玻璃体视网膜病变中纤维化包裹的手术治疗
Clin Ophthalmol. 2013;7:1093-8. doi: 10.2147/OPTH.S43939. Epub 2013 Jun 10.
3
Long-term effectiveness of ranibizumab for age-related macular degeneration and diabetic macular edema.雷珠单抗治疗年龄相关性黄斑变性和糖尿病性黄斑水肿的长期疗效。
Clin Interv Aging. 2013;8:467-83. doi: 10.2147/CIA.S36811. Epub 2013 Apr 29.
4
Differentiating vitreous proteomes in proliferative diabetic retinopathy using high-performance liquid chromatography coupled to tandem mass spectrometry.采用高效液相色谱-串联质谱技术对增生性糖尿病视网膜病变的玻璃体蛋白质组进行分析。
Exp Eye Res. 2013 Mar;108:110-9. doi: 10.1016/j.exer.2012.11.023. Epub 2012 Dec 28.
5
Enzymatic vitreolysis with ocriplasmin for vitreomacular traction and macular holes.
N Engl J Med. 2012 Nov 22;367(21):2053; author reply 2054. doi: 10.1056/NEJMc1211068.
6
Ang-2 upregulation correlates with increased levels of MMP-9, VEGF, EPO and TGFβ1 in diabetic eyes undergoing vitrectomy.在接受玻璃体切除术的糖尿病眼中，Ang-2 的上调与 MMP-9、VEGF、EPO 和 TGFβ1 水平的升高相关。
Acta Ophthalmol. 2013 Sep;91(6):531-9. doi: 10.1111/j.1755-3768.2012.02473.x. Epub 2012 Oct 26.
7
Proteomic analysis of vitreous biopsy techniques.玻璃体活检技术的蛋白质组学分析。
Retina. 2012 Nov-Dec;32(10):2141-9. doi: 10.1097/IAE.0b013e3182562017.
8
Inhibition of neovascularization but not fibrosis with the fluocinolone acetonide implant in autosomal dominant neovascular inflammatory vitreoretinopathy.醋酸氟轻松植入物对常染色体显性遗传性新生血管性炎症性玻璃体视网膜病变有抑制新生血管形成的作用，但对纤维化无效。
Arch Ophthalmol. 2012 Nov;130(11):1395-401. doi: 10.1001/archophthalmol.2012.1971.
9
Sequential in-office vitreous aspirates demonstrate vitreous matrix metalloproteinase 9 levels correlate with the amount of subretinal fluid in eyes with wet age-related macular degeneration.连续的门诊玻璃体抽吸术表明，在湿性年龄相关性黄斑变性患者眼中，玻璃体基质金属蛋白酶9水平与视网膜下液量相关。
Mol Vis. 2012;18:1658-67. Epub 2012 Jun 20.
10
Imbalanced levels of angiogenic and angiostatic factors in vitreous, plasma and postmortem retinal tissue of patients with proliferative diabetic retinopathy.增生型糖尿病视网膜病变患者玻璃体液、血浆和死后视网膜组织中血管生成和血管抑制因子水平失衡。
J Diabetes Complications. 2012 Sep-Oct;26(5):435-41. doi: 10.1016/j.jdiacomp.2012.05.005. Epub 2012 Jun 12.