Department of Clinical Sciences, University of Turku, Turku, Finland; Department of Paediatrics, Turku University Hospital, Turku, Finland; Functional Foods Forum, University of Turku, Turku, Finland.
Acta Paediatr. 2014 Feb;103(2):168-73. doi: 10.1111/apa.12458. Epub 2013 Dec 3.
To find out whether there was an association between when complementary feeding was introduced and the appearance of atopic eczema in children with a family history of allergy.
This prospective study followed 256 mother and child pairs until the child was four-years-old. Repeated skin prick testing was performed and a clinical diagnosis of eczema made by a physician. The mothers kept a continuous diary about the introduction of complementary feeding. To control the possible reverse causation of delaying complementary food introduction due to presumed child allergy, parental suspicions of allergic reactions were recorded.
The introduction of cereals and fish after seven-months-of-age was associated with an increased risk of atopic eczema. However, when the parents' suspicions that their child might be exhibiting symptoms of allergic disease were taken into account, this effect was no longer significant.
We found no evidence that the timing of the introduction of complementary feeding increased the risk of atopic eczema in a high-risk cohort, when parental suspicions were taken into account. Therefore, it seems that families with a history of allergy can safely comply with current feeding recommendations, although confirmation in further studies is warranted.
探讨有家族过敏史的儿童开始添加辅食的时间与特应性湿疹出现之间的关系。
本前瞻性研究随访了 256 对母婴，直至儿童 4 岁。对儿童进行了多次皮肤点刺试验，并由医生做出湿疹的临床诊断。母亲连续记录添加辅食的情况。为了控制因推测的儿童过敏而延迟添加辅食可能导致的反向因果关系，记录了父母对过敏反应的怀疑。
7 个月后添加谷类和鱼类与特应性湿疹的风险增加有关。然而，当考虑到父母怀疑孩子可能出现过敏症状时，这种影响不再显著。
当考虑到父母的怀疑时，我们没有发现有证据表明在高风险队列中，添加辅食的时间会增加特应性湿疹的风险。因此，有过敏史的家庭似乎可以安全地遵循当前的喂养建议，尽管还需要进一步研究证实。
