减重手术后的认知功能：术后 3 年改善的证据。
Cognitive function after bariatric surgery: evidence for improvement 3 years after surgery.
机构信息
Department of Psychology, Kent State University, 238 Kent Hall Addition, Kent, OH 44242, USA.
Department of Psychology, Kent State University, 238 Kent Hall Addition, Kent, OH 44242, USA; Summa Health System, Akron, OH, USA.
出版信息
Am J Surg. 2014 Jun;207(6):870-6. doi: 10.1016/j.amjsurg.2013.05.018. Epub 2013 Oct 10.
BACKGROUND
Bariatric surgery is associated with improved cognition, and it is possible that such improvements are found at extended follow-ups. We hypothesized that cognitive improvement would be maintained 3 years after bariatric surgery.
METHODS
Fifty bariatric patients were recruited from the Longitudinal Assessment of Bariatric Surgery parent project. Participants completed a computerized cognitive test battery to assess cognitive function at 12 weeks, 12 months, 24 months, and 36 months after surgery.
RESULTS
Repeated measures revealed main effects for attention, executive function, and memory. Attention improved up to 24 months and then slightly declined although it still fell within the average range at 36 months. Improvements in executive function reached their peak at 36 months after surgery. Short-term improvements in memory were maintained at 36 months. No main effect emerged for language.
CONCLUSIONS
Bariatric surgery may lead to lasting improvements in cognition. Prospective studies with extended follow-ups (eg, 10 years) should examine whether bariatric surgery can attenuate cognitive decline in severely obese patients.
背景
减重手术与认知能力的改善有关，而且这种改善可能在长期随访中发现。我们假设，在减重手术后 3 年，认知能力的改善将持续存在。
方法
从长期评估减重手术项目的母项目中招募了 50 名减重手术患者。参与者在手术后 12 周、12 个月、24 个月和 36 个月时完成了计算机认知测试。
结果
重复测量显示注意力、执行功能和记忆有主要影响。注意力改善至 24 个月，然后略有下降，但仍在 36 个月时处于平均范围内。手术后 36 个月时，执行功能的改善达到峰值。短期记忆的改善在 36 个月时保持。语言方面没有出现主要影响。
结论
减重手术可能会导致认知能力的持久改善。应进行前瞻性研究，并进行长期随访（例如 10 年），以观察减重手术是否可以减缓严重肥胖患者的认知能力下降。
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