大肠杆菌启动子序列中的一个常见结构特征。
A common structural feature in promoter sequences of E. coli.
作者信息
Tung C S, Harvey S C
出版信息
Nucleic Acids Res. 1987 Jun 25;15(12):4973-85. doi: 10.1093/nar/15.12.4973.
We have searched promoter regions of E. coli, structural genes of the same organism, and computer-generated random sequence DNA for the occurrence of common structural features. This is done by converting the base sequence to a series of numbers representing the sequence of helix twist angles and examining these numerical sequences statistically. Common structural features are shared by the promoter regions with a much higher frequency than are found in structural genes or in random sequences. These structures appear to be scattered randomly throughout the promoters, both in terms of the number of such structures per promoter and in terms of location within each promoter. One particular structure consisting of five successive helix twist angles is reported, along with a list of 60 different hexanucleotide sequences that share this structure. The locations of these structural elements in 61 E. coli promoters are also tabulated.
我们在大肠杆菌的启动子区域、同一生物体的结构基因以及计算机生成的随机序列DNA中搜索了常见结构特征的出现情况。这是通过将碱基序列转换为一系列代表螺旋扭转角序列的数字，并对这些数字序列进行统计分析来完成的。启动子区域共享的常见结构特征的频率远高于结构基因或随机序列中的频率。这些结构似乎在每个启动子中此类结构的数量以及在每个启动子内的位置方面，都随机散布在整个启动子中。报告了一种由五个连续螺旋扭转角组成的特定结构，以及一份共享此结构的60种不同六核苷酸序列的列表。还列出了这些结构元件在61个大肠杆菌启动子中的位置。
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