Rink C, Klaua M, Mertens E, Schneider G, Nilius R
Z Gesamte Inn Med. 1985 May 15;40(10):300-2.
The thyreostatic therapy of a hyperthyroidism in coincident chronic hepatopathy is problematic. On the one hand, this therapy may be an additional load, particularly by the development of a cholestasis for the ill liver. On the other hand, due to the hyperthyroidism disturbance of the liver function and liver diseases up to cholestatic hepatitis may develop. At the instance of two patients with liver cirrhosis, whose simultaneous hyperthyroidism was treated thyreostatically, the therapeutic problems are represented. On the basis of the treatment of a not small number of patients with this constellation of findings we recommend the use of Thiamazol as therapy of choice in the at present, usual lower initial dosage. If functional disturbances of the liver and other side effects appear under this therapy, the radio-iodine therapy offers itself as alternative.
伴有慢性肝病的甲状腺功能亢进症的抗甲状腺治疗存在问题。一方面，这种治疗可能会带来额外负担，尤其是因胆汁淤积的发生而加重患病肝脏的负担。另一方面，由于甲状腺功能亢进，可能会出现肝功能紊乱，甚至发展为胆汁淤积性肝炎。通过两名肝硬化患者同时接受抗甲状腺治疗的病例，展现了其中的治疗问题。基于对大量具有这种症状组合患者的治疗经验，我们推荐目前以常用的较低初始剂量使用甲巯咪唑作为首选治疗方法。如果在这种治疗下出现肝脏功能紊乱和其他副作用，放射性碘治疗可作为替代方案。
