Ockert C, Willgerodt H, Keller E, Senger H, Pludra R
Zentralbl Gynakol. 1985;107(12):744-51.
The alterations of the lipid metabolism produced by placental insufficiency were investigated in animal experiments. Pregnant rabbits received Chlormadinon-acetate by intramuscular injection. The pregnancy was prolongated for 4 days, and a placental insufficiency developed. The lipid metabolism of the mothers and the fetuses was investigated by determination of beta-lipoproteides, triglycerides, cholesterol and HDL- and LDL/VLDL-cholesterol. The most important result is an increase of the concentrations of triglycerides and cholesterol of the fetuses during prolongation of pregnancy. Of the different cholesterol fractions estimated the LDL/VLDL-cholesterol-ratio excellently reflects the changes of the lipid metabolism during prolonged pregnancy.
在动物实验中研究了胎盘功能不全所产生的脂质代谢变化。给怀孕的兔子肌肉注射醋酸氯地孕酮。孕期延长了4天，出现了胎盘功能不全。通过测定β-脂蛋白、甘油三酯、胆固醇以及高密度脂蛋白和低密度脂蛋白/极低密度脂蛋白胆固醇来研究母体和胎儿的脂质代谢。最重要的结果是孕期延长期间胎儿的甘油三酯和胆固醇浓度增加。在所估计的不同胆固醇组分中，低密度脂蛋白/极低密度脂蛋白胆固醇比率能很好地反映孕期延长期间脂质代谢的变化。
