TGFβ 在肿瘤微环境中的作用。
The roles of TGFβ in the tumour microenvironment.
机构信息
Vanderbilt University Medical Center, Vanderbilt-Ingram Comprehensive Cancer Center, Medicine and Pathology, Cancer Biology, 2220 Pierce Avenue, 691 Preston Research Building, Nashville, Tennessee 37232, USA.
出版信息
Nat Rev Cancer. 2013 Nov;13(11):788-99. doi: 10.1038/nrc3603. Epub 2013 Oct 17.
Abstract
The influence of the microenvironment on tumour progression is becoming clearer. In this Review we address the role of an essential signalling pathway, that of transforming growth factor-β, in the regulation of components of the tumour microenvironment and how this contributes to tumour progression.
摘要
微环境对肿瘤进展的影响正变得越来越清晰。在这篇综述中，我们探讨了一个基本信号通路——转化生长因子-β（TGF-β）在肿瘤微环境成分调控中的作用，以及它如何促进肿瘤进展。
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本文引用的文献
1
Epigenetic Alteration by DNA Promoter Hypermethylation of Genes Related to Transforming Growth Factor-β (TGF-β) Signaling in Cancer.
Cancers (Basel). 2011 Mar 3;3(1):982-93. doi: 10.3390/cancers3010982.
2
Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers.
J Clin Oncol. 2013 Jun 10;31(17):2205-18. doi: 10.1200/JCO.2012.46.3653. Epub 2013 May 13.
3
Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis.
Nat Commun. 2013;4:1795. doi: 10.1038/ncomms2766.
4
Transforming growth factor β1 induces the expression of collagen type I by DNA methylation in cardiac fibroblasts.
PLoS One. 2013;8(4):e60335. doi: 10.1371/journal.pone.0060335. Epub 2013 Apr 1.
5
The future of epigenetic therapy in solid tumours--lessons from the past.
Nat Rev Clin Oncol. 2013 May;10(5):256-66. doi: 10.1038/nrclinonc.2013.42. Epub 2013 Apr 2.
6
Transforming growth factor β-regulated microRNA-29a promotes angiogenesis through targeting the phosphatase and tensin homolog in endothelium.
J Biol Chem. 2013 Apr 12;288(15):10418-26. doi: 10.1074/jbc.M112.444463. Epub 2013 Feb 20.
7
Inflammation-mediated genetic and epigenetic alterations drive cancer development in the neighboring epithelium upon stromal abrogation of TGF-β signaling.
PLoS Genet. 2013;9(2):e1003251. doi: 10.1371/journal.pgen.1003251. Epub 2013 Feb 7.
8
Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer.
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9
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