Notch 和 gp130 信号在神经干细胞和祖细胞维持中的相互作用。
Interaction of Notch and gp130 signaling in the maintenance of neural stem and progenitor cells.
机构信息
Faculty of Science, Institute of Experimental Biology, Masaryk University, Brno, Czech Republic.
出版信息
Cell Mol Neurobiol. 2014 Jan;34(1):1-15. doi: 10.1007/s10571-013-9996-6. Epub 2013 Oct 17.
Notch and gp130 signaling are involved in the regulation of multiple cellular processes across various tissues during animal ontogenesis. In the developing nervous system, both signaling pathways intervene at many stages to determine cell fate-from the first neural lineage commitment and generation of neuronal precursors, to the terminal specification of cells as neurons and glia. In most cases, the effects of Notch and gp130 signaling in these processes are similar. The aim of the current review was to summarize the knowledge regarding the roles of Notch and gp130 signaling in the maintenance of neural stem and progenitor cells during animal ontogenesis, from early embryo to adult. Recent data show a direct crosstalk between these signaling pathways that seems to be specific for a particular type of neural progenitors.
Notch 和 gp130 信号通路参与调控动物个体发生过程中各种组织中的多种细胞过程。在发育中的神经系统中，这两条信号通路在多个阶段介入，以决定细胞命运——从第一个神经谱系的决定和神经元前体细胞的产生，到细胞作为神经元和神经胶质的终末特化。在大多数情况下，Notch 和 gp130 信号通路在这些过程中的作用是相似的。本综述的目的是总结 Notch 和 gp130 信号通路在动物个体发生过程中（从早期胚胎到成年）维持神经干细胞和祖细胞中的作用的相关知识。最近的数据表明，这两条信号通路之间存在直接的串扰，这种串扰似乎是特定类型的神经祖细胞所特有的。
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