Department of Preventive Medicine, Academy of Medicine, Lithuanian University of Health Sciences, Eivenių 4, Kaunas, LT-50161, Lithuania,
Support Care Cancer. 2014 Feb;22(2):519-26. doi: 10.1007/s00520-013-2005-2. Epub 2013 Oct 18.
The assessment of health-related quality of life (HRQL) in newly diagnosed breast cancer patients is necessary to address predictive factors in supportive clinical practice.
The objectives of this study are to evaluate self-reported HRQL within 1 year after breast cancer diagnosis and to determine important factors associated with self-reported impaired HRQL.
A cross-sectional study was performed in newly diagnosed breast cancer patients. The statistical analysis included descriptive statistics and stepwise logistic regression modeling.
The survey response rate was 67 % (n = 338). Almost 50 % of the studied population was identified as experiencing anxiety. The impaired HRQL domains were emotional functioning and global health status. Severely expressed symptoms included insomnia, fatigue, and financial difficulties. Poor financial situation, comorbidities, unemployment, and lack of psychological counseling were identified as important predictive factors (p < 0.001).
Psychosocial, but not clinical, factors were the prevalent predictive factors in impaired HRQL. Early identification of women that are at risk of poorer HRQL and interventions of psychosocial support following breast cancer diagnosis are recommended.
在新诊断的乳腺癌患者中评估与健康相关的生活质量（HRQL）对于支持性临床实践中的预测因素是必要的。
本研究的目的是评估乳腺癌诊断后 1 年内的自我报告 HRQL，并确定与自我报告受损 HRQL 相关的重要因素。
进行了一项横断面研究，纳入了新诊断的乳腺癌患者。统计分析包括描述性统计和逐步逻辑回归建模。
调查的回复率为 67%（n=338）。近 50%的研究人群被认为存在焦虑。受损的 HRQL 领域包括情绪功能和整体健康状况。严重表达的症状包括失眠、疲劳和经济困难。经济状况差、合并症、失业和缺乏心理咨询被确定为重要的预测因素（p<0.001）。
心理社会因素而非临床因素是导致 HRQL 受损的主要预测因素。建议早期识别存在较差 HRQL 风险的女性，并在乳腺癌诊断后进行心理社会支持干预。
