高血压前期作为无症状成年人诊断分类的相关性。

Relevance of prehypertension as a diagnostic category in asymptomatic adults.

作者信息

Nary Fernando Costa, Santos Raul D, Laurinavicius Antonio Gabriele, Conceição Raquel Dilguerian de Oliveira, Carvalho José Antonio Maluf de

出版信息

Einstein (Sao Paulo). 2013 Jul-Sep;11(3):303-9. doi: 10.1590/s1679-45082013000300008.

DOI:10.1590/s1679-45082013000300008

PMID:24136756

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4878588/

Abstract

OBJECTIVE

To assess the association of prehypertension with metabolic, inflammatory and cardiovascular risk profile in asymptomatic individuals.

METHODS

Between 2006 and 2009, 11,011 asymptomatic adults (mean age: 43 years; 22% females), underwent a check-up protocol. They were divided into 3 groups: normotensive group (arterial pressure=120/80mmHg), prehypertensive group (arterial pressure >120/80mmHg and <140/90mmHg) and hypertensive group (arterial pressure>140/90mmHg or prior diagnosis of hypertension). Each group metabolic and cardiovascular group profile was assessed.

RESULTS

The prevalence of normotension, prehypertension and hypertension was 27.9%, 53.9% and 18.2%, respectively. Prehypertensive individuals were older (mean age: 42.7 versus 40 years; p<0.001) than normotensive patients, and had higher body mass index (mean: 26.7kg/m² versus 24kg/m²; p<0.001), higher plasma triglycerides levels (mean: 139mg/dL versus 108mg/dL; p<0.001), higher LDL-choleterol levels (mean: 128mg/dL versus 117mg/dL; p<0.001), and lower HDL-cholesterol (mean: 46.7mg/dL versus 52.7mg/dL; p<0.001). Prehypertensive individuals were more likely to have impaired fasting glucose (OR: 1.69; 95%CI: 1.39-2.04), overweight and obesity - body mass index >25kg/m² (OR: 2.48; 95%CI: 2.24-2.74), hepatic steatosis: (OR: 2.23; 95%CI: 1.97-2.53), metabolic syndrome (OR: 3.05; 95%CI: 2.67-3.49), and high-sensitivity C-reactive protein levels>2mg/L (OR: 1.52; 95%CI: 1.35-1.71).

CONCLUSION

Prehypertension is associated with an increased prevalence of metabolic syndrome, hepatic steatosis and subclinical inflammation.

摘要

目的

评估无症状个体中高血压前期与代谢、炎症及心血管风险状况之间的关联。

方法

2006年至2009年间，11011名无症状成年人（平均年龄：43岁；22%为女性）接受了体检方案。他们被分为3组：正常血压组（动脉压 = 120/80mmHg）、高血压前期组（动脉压>120/80mmHg且<140/90mmHg）和高血压组（动脉压>140/90mmHg或既往有高血压诊断）。对每组的代谢和心血管状况进行了评估。

结果

正常血压、高血压前期和高血压的患病率分别为27.9%、53.9%和18.2%。高血压前期个体比正常血压患者年龄更大（平均年龄：42.7岁对40岁；p<0.001），且体重指数更高（平均：26.7kg/m²对24kg/m²；p<0.001），血浆甘油三酯水平更高（平均：139mg/dL对108mg/dL；p<0.001），低密度脂蛋白胆固醇水平更高（平均：128mg/dL对117mg/dL；p<0.001），高密度脂蛋白胆固醇更低（平均：46.7mg/dL对52.7mg/dL；p<0.001）。高血压前期个体更有可能出现空腹血糖受损（比值比：1.69；95%置信区间：1.39 - 2.04）、超重和肥胖——体重指数>25kg/m²（比值比：2.48；95%置信区间：2.24 - 2.74）、肝脂肪变性：（比值比：2.23；95%置信区间：1.97 - 2.53）、代谢综合征（比值比：3.05；95%置信区间：2.67 - 3.49）以及高敏C反应蛋白水平>2mg/L（比值比：1.52；95%置信区间：1.35 - 1.71）。