Serup J, Hagdrup H
Acta Derm Venereol. 1985;65(4):343-5.
Vitamin D metabolites in serum were analysed in 20 patients with generalized scleroderma. The concentration of 1,25-dihydroxyvitamin D was normal, however, significantly lower concentrations (p less than 0.05) were found in 7 patients with cutaneous calcinosis in comparison with 13 patients with no calcinosis. Concentrations of 25-hydroxyvitamin D, 24-25-dihydroxyvitamin D, and vitamin D-binding protein (Gc globulin) were all within the normal range. The 24,25-dihydroxy-vitamin D level correlated with the duration of disease (r = 0.4453, p less than 0.05), and 25-hydroxyvitamin D tended to correlate (r = 0.3016, NS). The study strongly indicates that cutaneous synthesis, intestinal absorption and hepatic hydroxylation of vitamin D are not deficient in scleroderma. A relative but specific decrease in the renal hydroxylation to 1,25-dihydroxyvitamin D, i.e. the active hormone, as the disease progresses and calcinosis occurs, is suspected.
对20例系统性硬皮病患者的血清维生素D代谢产物进行了分析。1,25 - 二羟维生素D的浓度正常，然而，与13例无皮肤钙化的患者相比，7例有皮肤钙化的患者其浓度显著降低（p < 0.05）。25 - 羟维生素D、24,25 - 二羟维生素D和维生素D结合蛋白（Gc球蛋白）的浓度均在正常范围内。24,25 - 二羟维生素D水平与病程相关（r = 0.4453，p < 0.05），25 - 羟维生素D有相关趋势（r = 0.3016，无显著性差异）。该研究有力地表明，硬皮病患者维生素D的皮肤合成、肠道吸收和肝脏羟化均无缺陷。随着疾病进展和钙化发生，怀疑肾脏将维生素D羟化为活性激素1,25 - 二羟维生素D的过程存在相对但特定的减少。
