Lundberg A C, Akesson A, Akesson B
Department of Rheumatology, University of Lund, Sweden.
Ann Rheum Dis. 1992 Oct;51(10):1143-8. doi: 10.1136/ard.51.10.1143.
Oesophageal dysmotility and abnormalities of intestinal function are important manifestations in systemic sclerosis and may have a significant effect on nutrient absorption and nutritional status. In this study 30 patients with systemic sclerosis with symptoms from the gastrointestinal tract were compared with matched healthy control subjects with respect to nutrient intake (four day record), anthropometric measurements, and biochemical nutritional status. The intake of energy (8.1 and 8.4 MJ/day) and its distribution among nutrients did not differ between patients and control subjects, but the lower intake of dietary fibre among patients with systemic sclerosis suggests that they avoided food with a coarse structure, such as coarse bread. The intake of vegetables and fruit also tended to be lower among patients with systemic sclerosis. Half of the patients had a subnormal arm muscle circumference, and two patients also had a subnormal triceps skinfold thickness, indicating severe malnutrition. The concentration of ascorbic acid, alpha-tocopherol, carotene, selenium, and also the proportion of linoleic acid (18:2) in serum phosphatidylcholine was lower in patients than in control subjects.
食管动力障碍和肠道功能异常是系统性硬化症的重要表现,可能对营养吸收和营养状况产生重大影响。在本研究中,将30例有胃肠道症状的系统性硬化症患者与匹配的健康对照者在营养摄入(四天记录)、人体测量和生化营养状况方面进行了比较。患者和对照者之间的能量摄入量(8.1和8.4兆焦/天)及其在营养素中的分布没有差异,但系统性硬化症患者膳食纤维摄入量较低,这表明他们避免食用结构粗糙的食物,如粗面包。系统性硬化症患者的蔬菜和水果摄入量也往往较低。一半的患者上臂肌肉周长低于正常,两名患者三头肌皮褶厚度也低于正常,表明存在严重营养不良。患者血清中抗坏血酸、α-生育酚、胡萝卜素、硒的浓度,以及血清磷脂酰胆碱中亚油酸(18:2)的比例均低于对照者。