放线菌素D对大肠杆菌RNA聚合酶转录T7噬菌体DNA的作用。
The action of actinomycin D on the transcription of T7 coliphage DNA by Escherichia coli RNA polymerase.
作者信息
Flamée P A
出版信息
Biochem J. 1985 Sep 1;230(2):557-60. doi: 10.1042/bj2300557.
Abstract
An actinomycin D molecule bound to DNA sometimes stops the synthesis of RNA by Escherichia coli RNA polymerase. However, quite often, the bound antibiotic is released before the RNA polymerase detaches from the template DNA, so that the enzyme can resume, without interruption, the synthesis of the RNA chain.
摘要
与DNA结合的放线菌素D分子有时会阻止大肠杆菌RNA聚合酶合成RNA。然而，通常情况下，在RNA聚合酶从模板DNA上脱离之前，结合的抗生素就会被释放，这样酶就能不间断地继续RNA链的合成。
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Optical properties of actinomycin D. I. Influence of the lactone rings on its optical activity.放线菌素D的光学性质。I. 内酯环对其旋光性的影响。
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