J Cutan Med Surg. 2013 Nov-Dec;17(6):398-403. doi: 10.2310/7750.2013.13052.
Studies have shown that psoriatic patients are at increased risk for myocardial infarction (MI) and stroke. There is a lack of data on MI risk in Canadian psoriatic patients.
To compare MI risk in Canadian psoriatic patients to that in control patients.
This was a retrospective cohort study using Quebec's health insurance database (2005-2010) comparing MI risk in psoriatic patients to that in matched controls. Severe psoriasis was defined as any diagnosed psoriatic patient who used phototherapy or oral or injectable psoriasis treatments. Adjustments were made for several MI risk factors.
There were 31,421 patients in the psoriasis population, of which 5,159 had severe psoriasis. The unadjusted MI incidence rate per 1,000 person-years was 4.88 (95% confidence interval [95% CI] 4.50-5.20), 5.58 (95% CI 5.10-6.10), and 5.32 (95% CI 4.40-6.40) for the control and mild and severe psoriasis groups, respectively. After adjustments, the hazard ratio of MI was significantly higher for psoriatic patients than for controls (1.17; 95% CI 1.04-1.31). The hazard ratio was also significantly higher than for controls in the mild psoriasis group (1.18; 95% CI 1.05-1.33) but not in the severe psoriasis group (1.16; 95% CI 0.94-1.42).
The relative MI risk is higher for Canadian psoriatic patients than for controls.
研究表明，银屑病患者发生心肌梗死（MI）和中风的风险增加。加拿大银屑病患者发生 MI 的风险数据不足。
比较加拿大银屑病患者的 MI 风险与对照患者的 MI 风险。
这是一项回顾性队列研究，利用魁北克省的健康保险数据库（2005-2010 年），比较了银屑病患者和匹配对照患者的 MI 风险。严重银屑病定义为任何诊断为银屑病的患者，他们使用光疗或口服或注射性银屑病治疗。对多种 MI 危险因素进行了调整。
在银屑病患者人群中有 31421 例患者，其中 5159 例患者患有严重银屑病。未调整的每 1000 人年 MI 发生率为 4.88（95%置信区间 [95%CI] 4.50-5.20）、5.58（95%CI 5.10-6.10）和 5.32（95%CI 4.40-6.40），分别为对照、轻度和重度银屑病组。调整后，与对照组相比，银屑病患者的 MI 风险比显著更高（1.17；95%CI 1.04-1.31）。与对照组相比，轻度银屑病组的风险比也显著更高（1.18；95%CI 1.05-1.33），但在重度银屑病组中没有（1.16；95%CI 0.94-1.42）。
与对照组相比，加拿大银屑病患者的相对 MI 风险更高。
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