The University of Queensland, Centre for Clinical Research, Herston, Australia; The University of Queensland, School of Dentistry, Brisbane, Australia.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Dec;116(6):725-33. doi: 10.1016/j.oooo.2013.08.005. Epub 2013 Oct 18.
Clinical identification of underlying histopathology of oral mucosal lesions (OMLs) remains difficult. The study aims to identify clinical indicators of underlying histopathology of oral malignant and potentially malignant disorders.
All clinical patient records of an oral medicine and pathology clinic over a 12-year period were manually searched. Cases of OMLs with a histopathologic diagnosis of dysplasia (n = 124) and malignancy (n = 27) and a sample of nondysplastic OMLs (n = 109) were analyzed using both univariate and multivariate analysis and odds ratios for an association with clinical characteristics.
A nonhomogeneous clinical appearance was strongly associated with underlying dysplasia in both univariate and multivariate analysis (P < .001; odds ratio, 4.4). For lesions with homogeneous appearance, dysplasia was associated with lesion location (P = .005; odds ratio, 2.6) and smoking history (P = .04).
These findings suggest that a nonhomogeneous mucosal lesion is a significant independent indicator for underlying oral epithelial dysplasia, with location, size, and color as additional contributing factors.
口腔黏膜病变（OML）的潜在组织病理学临床识别仍然具有挑战性。本研究旨在确定口腔恶性和潜在恶性疾病的潜在组织病理学的临床指标。
对一个口腔医学和病理学诊所 12 年来的所有临床患者记录进行了手动搜索。对具有发育不良（n = 124）和恶性（n = 27）组织病理学诊断的 OML 病例和非发育不良 OML 样本（n = 109）进行了分析，使用单变量和多变量分析以及与临床特征相关的比值比。
在单变量和多变量分析中，非均一的临床外观与潜在发育不良密切相关（P <.001；比值比，4.4）。对于具有均一外观的病变，发育不良与病变位置（P =.005；比值比，2.6）和吸烟史（P =.04）相关。
这些发现表明，非均一的黏膜病变是潜在口腔上皮发育不良的一个重要独立指标，位置、大小和颜色是额外的影响因素。
