Translational Clinical Neurophysiology Unit, Instituto de Medicina Molecular and Institute of Physiology, Faculty of Medicine, University of Lisbon, Lisbon, Portugal2Department of Neurosciences, Hospital de Santa Maria, Lisbon, Portugal.
Translational Clinical Neurophysiology Unit, Instituto de Medicina Molecular and Institute of Physiology, Faculty of Medicine, University of Lisbon, Lisbon, Portugal3Department of Neurology, Royal London Hospital, Queen Mary University of London, London.
JAMA Neurol. 2013 Dec;70(12):1562-5. doi: 10.1001/jamaneurol.2013.4437.
Fasciculation potentials (FPs) may arise proximally or distally within the peripheral nervous system. We recorded FPs in the tibialis anterior using 2 concentric needle electrodes, ensuring by slight voluntary contraction and electrical nerve stimulation that each electrode recorded motor unit potentials innervated by different axons.
Time-locked FPs recorded from both electrodes, suggesting a spinal origin, were most frequent in benign fasciculation syndrome (44%) (P < .001) and amyotrophic lateral sclerosis without reinnervation (27%). Fewer time-locked FPs were found (14%) in the reinnervated tibialis anterior in amyotrophic lateral sclerosis (P < .001).
We conclude that in chronic partial denervation FPs are more likely to arise distally and that FPs in benign fasciculation syndrome more frequently arise proximally.
肌束震颤电位（FPs）可能在周围神经系统的近端或远端产生。我们使用 2 个同心针电极在前胫骨肌中记录 FPs，通过轻微的自愿收缩和电神经刺激确保每个电极记录由不同轴突支配的运动单位电位。
从两个电极记录的时间锁定 FPs，提示起源于脊髓，在良性肌束震颤综合征（44%）（P <.001）和无再支配的肌萎缩侧索硬化症（27%）中最常见。在前胫骨肌中发现的时间锁定 FPs 较少（14%），在肌萎缩侧索硬化症中有再支配（P <.001）。
我们得出结论，在慢性部分去神经支配中，FPs 更有可能在远端产生，而良性肌束震颤综合征中的 FPs 更常近端产生。
