紫穗槐果实的抗菌及伤口愈合活性评估
Evaluation of anti-bacterial and wound healing activity of the fruits of Amorpha fruticosa L.
作者信息
Qu Xueling, Diao Yunpeng, Zhang Zhen, Wang Shouyu, Jia Yujie
机构信息
Department of Pathophysiology, Dalian Medical University, Dalian, Liaoning Province, China 116011.
出版信息
Afr J Tradit Complement Altern Med. 2013 Apr 12;10(3):458-68. doi: 10.4314/ajtcam.v10i3.12. eCollection 2013.
As the traditional Chinese medicine, the fresh fruits of Amorpha fruticosa L. were applied for the treatment of carbuncle, eczema and burn (Das et al., 2007). However, little is known about the functional roles of the fruits of Amorpha fruticosa L. during wound healing progress. In the present study, we evaluated both antimicrobial potential against a wide range of microorganisms and wound healing activity of the seven compounds isolated from the fruits of Amorpha fruticosa L in vitro and in vivo. Our results showed that compounds I (6a,12a-dehydroamorphin), V (dehydrosermundone) and VI (tephrosin) isolated from the fruits of Amorpha fruticosa L. performed dominant antimicrobial potential against microorganisms. Moreover, these compounds significantly enhanced fibroblasts proliferation and migration, leading to promotion of wound healing. Thus, it could be possible for the therapeutic utilization of Amorpha fruticosa L. for wound healing in the future.
作为传统中药，紫穗槐的新鲜果实被用于治疗痈、湿疹和烧伤（达斯等人，2007年）。然而，关于紫穗槐果实在伤口愈合过程中的功能作用知之甚少。在本研究中，我们在体外和体内评估了从紫穗槐果实中分离出的七种化合物对多种微生物的抗菌潜力以及伤口愈合活性。我们的结果表明，从紫穗槐果实中分离出的化合物I（6a，12a - 脱氢紫穗槐素）、V（脱水瑟蒙德酮）和VI（灰叶素）对微生物具有主要的抗菌潜力。此外，这些化合物显著增强了成纤维细胞的增殖和迁移，从而促进了伤口愈合。因此，紫穗槐在未来有可能用于伤口愈合的治疗。
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