Palipoch Sarawoot
School of Medicine, Walailak University, Nakhon Si Thammarat, 80161, Thailand.
Afr J Tradit Complement Altern Med. 2013 May 16;10(4):88-93. doi: 10.4314/ajtcam.v10i4.15. eCollection 2013.
Acute kidney injury (AKI) is the common clinical syndrome which is associated with increased morbidity and mortality. The severity extends from less to more advanced spectrums which link to biological, physical and chemical agents. Oxidative stress (OS)-related AKI has demonstrated the increasing of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and the decreasing of endogenous antioxidants. Medicinal plants-derived antioxidants can be ameliorated oxidative stress-related AKI through reduction of lipid peroxidation (LPO) and enhancement of activities and levels of endogenous antioxidants. Therefore, medicinal plants are good sources of exogenous antioxidants which might be considered the important remedies to ameliorate pathological alterations in oxidative stress-related AKI.
急性肾损伤(AKI)是一种常见的临床综合征,与发病率和死亡率的增加相关。其严重程度从较轻到较严重不等,与生物、物理和化学因素有关。氧化应激(OS)相关的急性肾损伤表现为活性氧(ROS)和活性氮(RNS)增加以及内源性抗氧化剂减少。药用植物衍生的抗氧化剂可通过减少脂质过氧化(LPO)以及增强内源性抗氧化剂的活性和水平来改善氧化应激相关的急性肾损伤。因此,药用植物是外源性抗氧化剂的良好来源,可能被视为改善氧化应激相关急性肾损伤病理改变的重要药物。